DL-Mevalonolactone-d7
Based on 1 Customer Validation
DL-Mevalonolactone-d7 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling.
For research use only. We do not sell to patients.
- Purity: 99.27%
- CAS No.: 347840-19-1
- Formula: C6H3D7O3
- Molecular Weight:137.18
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 347840-19-1
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Unlabeled Cas 674-26-0
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Appearance Liquid
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Molecular Weight 137.18
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Formula C6H3D7O3
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Color Colorless to light yellow
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SMILES
OC1(CC(OC([2H])([2H])C1([2H])[2H])=O)C([2H])([2H])[2H]
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Synonyms
(±)-Mevalonolactone-d7; Mevalolactone-d7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (728.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (364.48 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310. [Content Brief]
[3]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 7.2897 mL | 36.4485 mL | 72.8969 mL | 182.2423 mL |
| 5 mM | 1.4579 mL | 7.2897 mL | 14.5794 mL | 36.4485 mL | |
| 10 mM | 0.7290 mL | 3.6448 mL | 7.2897 mL | 18.2242 mL | |
| 15 mM | 0.4860 mL | 2.4299 mL | 4.8598 mL | 12.1495 mL | |
| 20 mM | 0.3645 mL | 1.8224 mL | 3.6448 mL | 9.1121 mL | |
| 25 mM | 0.2916 mL | 1.4579 mL | 2.9159 mL | 7.2897 mL | |
| 30 mM | 0.2430 mL | 1.2149 mL | 2.4299 mL | 6.0747 mL | |
| 40 mM | 0.1822 mL | 0.9112 mL | 1.8224 mL | 4.5561 mL | |
| 50 mM | 0.1458 mL | 0.7290 mL | 1.4579 mL | 3.6448 mL | |
| 60 mM | 0.1215 mL | 0.6075 mL | 1.2149 mL | 3.0374 mL | |
| 80 mM | 0.0911 mL | 0.4556 mL | 0.9112 mL | 2.2780 mL | |
| 100 mM | 0.0729 mL | 0.3645 mL | 0.7290 mL | 1.8224 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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