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Cat. No.: HY-N12150

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Isozedoarondiol

Isozedoarondiol can be isolated from the rhizomes of Curcuma xanthorrhiza Roxb. Isozedoarondiol inhibits MMP-1 expression in UVB-treated human keratinocytes.

For research use only. We do not sell to patients.

CAS No.: 108887-68-9
Formula: C₁₅H₂₄O₃
Molecular Weight:252.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Isozedoarondiol Chemical Structure

CAS No.: 108887-68-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isozedoarondiol can be isolated from the rhizomes of Curcuma xanthorrhiza Roxb. Isozedoarondiol inhibits MMP-1 expression in UVB-treated human keratinocytes^[1].

All MMP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	>50 μg/mL Compound: 4	Cytotoxicity against human KB cells assessed as reduction in cell viability Cytotoxicity against human KB cells assessed as reduction in cell viability	[PMID: 29274817]
KG-1a	IC₅₀	>100 μg/mL Compound: 4	Cytotoxicity against human KG1a cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human KG1a cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29274817]
MCF7	IC₅₀	>50 μg/mL Compound: 4	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability Cytotoxicity against human MCF7 cells assessed as reduction in cell viability	[PMID: 29274817]
NCI-H187	IC₅₀	>50 μg/mL Compound: 4	Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability	[PMID: 29274817]
RAW264.7	IC₅₀	54.2 μM Compound: 19	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 23755850]

Chemical Information

CAS No. 108887-68-9
Molecular Weight 252.35
Formula C₁₅H₂₄O₃
SMILES

C[C@]1([C@]2([H])[C@](CC1)([H])[C@](O)(CC(/C(C2)=C(C)/C)=O)C)O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Park J-H, Mohamed MAA, Thi NN, et al. Guaiane Sesquiterpenes from the Rhizome of Curcuma xanthorrhiza and Their Inhibitory Effects on UVB-induced MMP-1 Expression in Human Keratinocytes. Natural Product Communications. 2017;12(10).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Isozedoarondiol

High-Throughput Bioactive Compound Library

All MMP Isoforms