MMP-9-IN-4 

MMP-9-IN-4 is a MMP-9 inhibitor (IC₅₀: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits _AKT activity (IC₅₀: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers^[1].

MMP-9-IN-4 (compound 11, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells^[1].
MMP-9-IN-4 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively^[1].
MMP-9-IN-4 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively ^[1].
MMP-9-IN-4 (2.2 nM, 24 h) inhibits cell migration in HepG-2 cells^[1].
MMP-9-IN-4 has anti-bacterial activity against E.coli with a MIC value of 1.814 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

564.47

C₂₈H₁₉F₃N₄O₆

2581824-39-5

O=C(C(N(C1=CC=CC=C1)C(C2=CC=C(C=C2)C(F)(F)F)=O)C3=CC=C(C=C3)[N+]([O-])=O)NC4=CC=C(C=C4)[N+]([O-])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mohammed Salah Ayoup, et al. Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis. Eur J Med Chem. 2020 Jan 15;186:111875.  [Content Brief]