1. Metabolic Enzyme/Protease
    PI3K/Akt/mTOR
    Apoptosis
  2. MMP
    Akt
    Apoptosis
  3. MMP-9-IN-4

MMP-9-IN-4 

Cat. No.: HY-146217
Handling Instructions

MMP-9-IN-4 is a MMP-9 inhibitor (IC50: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits AKT activity (IC50: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers.

For research use only. We do not sell to patients.

MMP-9-IN-4 Chemical Structure

MMP-9-IN-4 Chemical Structure

CAS No. : 2581824-39-5

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Description

MMP-9-IN-4 is a MMP-9 inhibitor (IC50: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits AKT activity (IC50: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers[1].

IC50 & Target[1]

MMP-9

7.46 nM (IC50)

MMP-1

41 nM (IC50)

MMP-2

139 nM (IC50)

MMP-13

113 nM (IC50)

AKT

8.82 nM (IC50)

In Vitro

MMP-9-IN-4 (compound 11, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1].
MMP-9-IN-4 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively[1].
MMP-9-IN-4 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively [1].
MMP-9-IN-4 (2.2 nM, 24 h) inhibits cell migration in HepG-2 cells[1].
MMP-9-IN-4 has anti-bacterial activity against E.coli with a MIC value of 1.814 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Wi-38, MCF-7, NFS-60, HepG-2 cells
Concentration: 0-1 μM approximately
Incubation Time: 72 h
Result: Showed cytotoxicity with IC50s: 374 nM (Wi-38), 3.6 nM (MCF-7), 3.61 nM (NFS-60), 2.2 nM (HepG-2).

Cell Migration Assay [1]

Cell Line: HepG-2
Concentration: 2.2 nM
Incubation Time: 24 h
Result: Inhibited cell migration by 93.77%.
Molecular Weight

564.47

Formula

C28H19F3N4O6

CAS No.
SMILES

O=C(C(N(C1=CC=CC=C1)C(C2=CC=C(C=C2)C(F)(F)F)=O)C3=CC=C(C=C3)[N+]([O-])=O)NC4=CC=C(C=C4)[N+]([O-])=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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MMP-9-IN-4
Cat. No.:
HY-146217
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