1. Membrane Transporter/Ion Channel
    Apoptosis
  2. P-glycoprotein
    Apoptosis
  3. Solamargine

Solamargine (Synonyms: Solamargin; δ-Solanigrine)

Cat. No.: HY-N0069 Purity: ≥98.0%
Handling Instructions

Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity.

For research use only. We do not sell to patients.

Solamargine Chemical Structure

Solamargine Chemical Structure

CAS No. : 20311-51-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 206 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 206 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 816 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 9 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Solamargine purchased from MCE. Usage Cited in: Int J Oncol. 2019 Mar;54(3):905-915. 

    Western blot analysis for the protein expression of XIAP, survivin, Ki‑67, PCNA and cyclin D1 in the treatment of MOCK, solamargine and Fe3O4-solamargine.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity[1][2].

    In Vitro

    Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis[3].
    Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC50s are 9.21 and 19.88 μg/ml, respectively[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[3]

    Cell Line: SMMC-7721cells
    Concentration: 15 μg/ml
    Incubation Time: 72 hours
    Result: Displayed a significant increase of sub-G1.
    In Vivo

    Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old)[4]
    Dosage: 10 mg/kg
    Administration: Intragastric administration; once daily for 8 days
    Result: Tumor growth was significantly inhibited .
    Molecular Weight

    868.06

    Formula

    C₄₅H₇₃NO₁₅

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (115.20 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1520 mL 5.7600 mL 11.5199 mL
    5 mM 0.2304 mL 1.1520 mL 2.3040 mL
    10 mM 0.1152 mL 0.5760 mL 1.1520 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: ≥98.0%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Solamargine
    Cat. No.:
    HY-N0069
    Quantity:
    MCE Japan Authorized Agent: