The cytotoxic principles of Solanum incanum

  • J Nat Prod. 1990 Mar-Apr;53(2):513-6. doi: 10.1021/np50068a041.
C N Lin  1 ,  C M Lu ,  M K Cheng ,  K H Gan ,  S J Won
Affiliations
  • 1. School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
PMID: 2380724 DOI: 10.1021/np50068a041
Abstract

In continuation of work on Solanum incanum a new steroidal alkaloid glycoside has been isolated from the fresh berries, which is named incanumine, and characterized as O(3)-[beta-D-xylopyranosyl-(1----3glu)-[beta-D-xylopyranosyl-(1--- -4rha)- alpha-L-rhamnopyranosyl-(1----4)]-beta-D-glucopyranosyl)-solasodine++ +. Solamargine, solasodine, ursolic acid, and ursolic acid derivatives (3-O-palmitoyl ursolic acid, 3-O-crotonyl ursolic acid, 3-O-propionyl ursolic acid) exhibited significant cytotoxic effects against human PLC/PRF/5 cells in vitro. Esterification of ursolic acid with aliphatic acids clearly enhanced the cytotoxic effects against human PLC/PRF/5 cells in vitro.