MMP-13-IN-1

Cat. No.: HY-154868: FAQs
Data Sheet Handling Instructions

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MMP-13-IN-1 is a potent and selective inhibitor of MMP-13 with a IC₅₀ value of 16 nM. MMP-13-in-1 can be used for atherosclerosis research.

For research use only. We do not sell to patients.

MMP-13-IN-1 Chemical Structure

CAS No. : 2925249-49-4

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Biological Activity
Purity & Documentation
References
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Description

MMP-13-IN-1 is a potent and selective inhibitor of MMP-13 with a IC₅₀ value of 16 nM. MMP-13-in-1 can be used for atherosclerosis research^[1].

IC₅₀ & Target^[1]

MMP13

16 nM (IC₅₀)

In Vivo

MMP-13-IN-1 (compound 5j) (2.5 mg/kg; i.v., 15 min before the use of the radiotracer) shows low uptake in metabolic organs with minimal retention of myocardial radioactivity, substantialrenal clearance, and high metabolic stability in ApoE^−/− mice models^[1].
. MMP-13-IN-1 (compound 5j) (2.5 mg/kg; i.v., 15 min before the use of the radiotracer) displays the highest overall uptake and the greatest colocalization to ORO-positive regions^[1]..

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	ApoE^−/− mice models^[1]
Dosage:	2.5 mg/kg
Administration:	Intravenous injection (i.v.); intravenously administered 15 min prior to the radiotracer
Result:	Blood radioactivity continued to decrease between 30 and 60 min and stabilized thereafter. Displayed a significant reduction in liver uptake. Relatively low levels of radioactivity were observed in all other measured organs except for the pancreas and spleen. Resulted in a 23% decrease in aortic plaque uptake , indicating an extent of saturable binding.

Molecular Weight

391.34

Formula

C₁₉H₁₆F₃N₃O₃

CAS No.

2925249-49-4

SMILES

FC(C(C)=C1)=CC=C1CNC(C2=NC3=C(C(N2)=O)C(OCCF)=C(C=C3)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Buchler A, et al. Quinazoline-2-Carboxamides as Selective PET Radiotracers for Matrix Metalloproteinase-13 Imaging in Atherosclerosis. J Med Chem. 2023 May 25;66(10):6682-6696. [Content Brief]

MMP-13-IN-1 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMP-13-IN-12925249-49-4MMPMatrix metalloproteinasesatherosclerosisApoE^?/? miceradiotracerInhibitorinhibitorinhibit

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