CIL-102
CIL-102, an apoptosis inducer, is a MMP-2/MMP-9 inhibitor that decreases MMP-2/MMP-9 protein expression and mRNA levels. CIL-102 displays an anti-cancer activity.
For research use only. We do not sell to patients.
- CAS No.: 479077-76-4
- Formula: C19H14N2O2
- Molecular Weight:302.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MMP-2 |
MMP-9 |
In human leukemia K562 cells, CIL-102 induces JNK and p38 MAPK activation but reduces the phospho-ERK level. CIL-102-induced p38 MAPK/JNK activation led to protein phosphatase 2A-mediated tristetraprolin (TTP) down-regulation. Moreover, CIL-102 reduces invasion and MMP-2/MMP-9 expression in breast and liver cancer cells[1].
CIL-102 results in triggering the extrinsic apoptosis pathway through the activation of Fas-L, caspase-8 and the induction of Bid cleavage and cytochrome c release in a time-dependent manner in DLD-1 cells. CIL-102 mediates apoptosis and G2/M arrest by phosphorylation of the JNK1/2 signaling pathway. This resulted in the expression of NFκB p50, p300 and CREB-binding protein (CBP) levels, and in the induction of p21 and GADD45 as well as the decreased association of cdc2/cyclin B. Collectively, CIL-102 induces cell cycle arrest and apoptosis of colon cancer cells by upregulating p21 and GADD45 expression and by activating JNK1/2, NFκB p50 and p300[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 479077-76-4
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Molecular Weight 302.33
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Formula C19H14N2O2
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SMILES
CC(C1=CC=C(NC2=C3C(OC=C3)=NC4=CC=CC=C24)C=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Liu WH, et al. CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability. Int J Biochem Cell Biol. 2012 Dec;44(12):2212-22. [Content Brief]
[2]. Huang WS, et al. CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45. PLoS One. 2017 Jan 9;12(1):e0168989. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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