1. Metabolic Enzyme/Protease
    Apoptosis
  2. MMP
    Apoptosis
  3. MMP2-IN-1

MMP2-IN-1 

Cat. No.: HY-146754
Handling Instructions

MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis.

For research use only. We do not sell to patients.

MMP2-IN-1 Chemical Structure

MMP2-IN-1 Chemical Structure

CAS No. : 2764598-01-6

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Description

MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis[1].

IC50 & Target[1]

MMP2

6.8 μM (IC50)

In Vitro

MMP2-IN-1 (compound 4a) (0-10 μM; 74 hours) exhibits IC50 values of 0.07 μM, 0.11 μM, and 0.18 μM against MDA-MB-231, A549, and HeLa cancer cells, respectively, and over 10 μM in Hep 5G cells[1].
MMP2-IN-1 (10 μM; 24 hours) induces cell cycle arrest in the S phase[1].
MMP2-IN-1 (0.01 μM, 0.1 μM, 1 μM and 10 μM; 24 hours) induces a dose-dependent increment in early-and late-stage apoptosis of MDA-MB-231 cells, and increased the early-stage apoptosis percentage from 4.66% to 10.9% at 10 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: MDA-MB-231, A549, HeLa and Hep 5G cells[1]
Concentration: 0-10 μM
Incubation Time: 74 hours
Result: Exhibited IC50 values of 0.07 μM, 0.11 μM, and 0.18 μM against MDA-MB-231, A549, and HeLa cancer cells, respectively, and over 10 μM in Hep 5G cells.

Cell Cycle Analysis

Cell Line: MDA-MB-231[1]
Concentration: 10 μM
Incubation Time: 24 hours
Result: Induced cell cycle arrest in the S phase.

Apoptosis Analysis

Cell Line: MDA-MB-231[1]
Concentration: 0.01 μM, 0.1 μM, 1 μM and 10 μM
Incubation Time: 24 hours
Result: Induced a dose-dependent increment in early-and late-stage apoptosis of MDA-MB-231 cells, and increased the early-stage apoptosis percentage from 4.66% to 10.9% at 10 μM.
In Vivo

MMP2-IN-1 (100 mg/kg, 150 mg/kg, 200 mg/kg, 250 mg/kg; IP, single) causes 0%, 30%, 50% and 60% mortality rate at dosing 100 mg/kg, 150 mg/kg, 200 mg/kg and 250 mg/kg respectively[1].
MMP2-IN-1 (10 mg/kg; IP, daily, for 14 days) significantly inhibits tumor growth in metastatic 4T1 murine breast cancer model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (n = 10, half male and half female)[1]
Dosage: 100 mg/kg, 150 mg/kg, 200 mg/kg, 250 mg/kg
Administration: IP, single
Result: No mortality occurred after administration of 100 mg/kg, and the mortality rate was 30%, 50% and 60% at dosing 150 mg/kg, 200 mg/kg, 250 mg/kg respectively.
Animal Model: Orthotopic 4T1 tumor-bearing mice[1]
Dosage: 10 mg/kg
Administration: IP, daily, for 14 days
Result: Significantly inhibited tumor growth in metastatic 4T1 murine breast cancer model.
Molecular Weight

319.33

Formula

C15H13NO5S

CAS No.
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Storage

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References
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MMP2-IN-1
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