1. Metabolic Enzyme/Protease
    PI3K/Akt/mTOR
    Apoptosis
  2. MMP
    Akt
    Apoptosis
  3. MMP-9-IN-5

MMP-9-IN-5 

Cat. No.: HY-146218
Handling Instructions

MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity (IC50: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers.

For research use only. We do not sell to patients.

MMP-9-IN-5 Chemical Structure

MMP-9-IN-5 Chemical Structure

CAS No. : 2581824-80-6

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Description

MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity (IC50: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers[1].

IC50 & Target[1]

MMP-9

4.49 nM (IC50)

MMP-1

104 nM (IC50)

MMP-2

266 nM (IC50)

MMP-13

280 nM (IC50)

AKT

1.34 nM (IC50)

In Vitro

MMP-9-IN-5 (compound 8, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1].
MMP-9-IN-5 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively[1].
MMP-9-IN-5 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively [1].
MMP-9-IN-5 (3.1 nM, 24 h) inhibits cell migration in HepG-2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Wi-38, MCF-7, NFS-60, HepG-2 cells
Concentration: 0-1 μM approximately
Incubation Time: 72 h
Result: Showed cytotoxicity with IC50s: 35.1 nM (Wi-38), 6.9 nM (MCF-7), 5.5 nM (NFS-60), 3.1 nM (HepG-2).

Cell Migration Assay [1]

Cell Line: HepG-2
Concentration: 3.1 nM
Incubation Time: 24 h
Result: Inhibited cell migration by 59.35%.
Molecular Weight

577.37

Formula

C27H20IN3O4

CAS No.
SMILES

O=C(C(N(C1=CC=CC=C1)C(C2=C(I)C=CC=C2)=O)C3=CC=CC=C3)NC4=CC=C(C=C4)[N+]([O-])=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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MMP-9-IN-5
Cat. No.:
HY-146218
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