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1142

Inhibitors & Agonists

6

Peptides

9

Inhibitory Antibodies

43

Natural
Products

486

Recombinant Proteins

13

Isotope-Labeled Compounds

352

Antibodies

989

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1724
    Concanamycin A
    Maximum Cited Publications
    27 Publications Verification

    Antibiotic X 4357B; Folimycin; X 4357B

    Proton Pump Bacterial Antibiotic Infection Inflammation/Immunology Cancer
    Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H +-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research - .
    Concanamycin A
  • HY-N0692
    Schisandrol B
    2 Publications Verification

    Gomisin-A; TJN-101; Wuweizi alcohol-B

    Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy Cancer
    Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
    Schisandrol B
  • HY-B2209
    Hydroxocobalamin
    3 Publications Verification

    Vitamin B12a

    Endogenous Metabolite Neurological Disease Metabolic Disease
    Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B12 deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease .
    Hydroxocobalamin
  • HY-B2209A
    Hydroxocobalamin monohydrochloride
    3 Publications Verification

    Vitamin B12a monohydrochloride

    Endogenous Metabolite Metabolic Disease
    Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia .
    Hydroxocobalamin monohydrochloride
  • HY-15308
    Avermectin B1a
    1 Publications Verification

    Abamectin B1a

    Parasite Antibiotic Infection
    Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.
    Avermectin B1a
  • HY-15311
    Avermectin B1
    5 Publications Verification

    Abamectin; Avermectin B1a-Avermectin B1b mixt.

    Environmental Pollutants Antibiotic Autophagy Parasite Apoptosis Reactive Oxygen Species (ROS) Infection Inflammation/Immunology
    Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy .
    Avermectin B1
  • HY-B2209B
    Hydroxocobalamin acetate
    3 Publications Verification

    Vitamin B12a acetate

    NO Synthase Cardiovascular Disease Metabolic Disease
    Hydroxocobalamin acetate is an injectable natural vitamin B12. Hydroxocobalamin acetate binds to NO. Hydroxocobalamin acetate detoxifies Cyanide and NaSH. Hydroxocobalamin acetate reduces hypotension. Hydroxocobalamin acetate is used in research related to vitamin B12 deficiency, including pernicious anemia .
    Hydroxocobalamin acetate
  • HY-126937
    Ivermectin B1a
    1 Publications Verification

    Parasite SARS-CoV Infection
    Ivermectin B1a, a derivative of Avermectin B1a (HY-15308), is a main component of Ivermectin (HY-15310) . Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .
    Ivermectin B1a
  • HY-P990764

    SGN-B6A antibody

    Integrin ADC Antibody Inflammation/Immunology Cancer
    Sigvotatug (SGN-B6A antibody) is a human IgG1 κ monoclonal antibody against ITGB6. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). Sigvotatug can be used as an ADC antibody to synthesize ADC Sigvotatug vedotin (HY-164957) .
    Sigvotatug
  • HY-N6013

    MMP Proteasome Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Bacterial Fungal Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .
    Aloin (mixture of A&B)
  • HY-100683

    Phosphatase Cancer
    A12B4C3 is a potent human polynucleotide kinase/phosphatase (hPNKP) inhibitor with an IC50 value of 0.06 μM. A12B4C3 has antiproliferative activity against cancer cells. A12B4C3 can also enhance the radiosensitivity of certain cancer cells .
    A12B4C3
  • HY-B1387

    Antibiotic Bacterial Inflammation/Immunology
    Sulfamethoxypyridazine is an orally active and brain-penetrant sulfonamide antibiotic. Sulfamethoxypyridazine exhibits antibacterial activity and inhibits growth of susceptible bacterial strains. Sulfamethoxypyridazine can be used for the research of pyelonephritis, urinary tract infections, and dermatitis herpetiformis .
    Sulfamethoxypyridazine
  • HY-169003

    Virus Protease Infection Neurological Disease Cancer
    STT3A/B-IN-1 is an orally active STT3A/B inhibitor with antiviral activity. STT3A/B-IN-1 upregulates DERL3 gene expression levels. STT3A/B-IN-1 is promising for research of viral diseases, including cancer and neurodegenerative disorders .
    STT3A/B-IN-1
  • HY-114267

    mTOR Others
    Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).
    Cbz-B3A
  • HY-163626A

    DAPK Cancer
    STK17A/B-IN-1 hydrochloride is an orally active, potent and selective STK17A/B inhibitor with an IC50 value of 23 nM for STK17A. STK17A/B-IN-1 hydrochloride can be used in tumor research .
    STK17A/B-IN-1 hydrochloride
  • HY-175729

    CDK Cancer
    Cyclin A/B RxL-IN-1 is a inhibitor targeting the Cyclin A/B RxL interaction at the hydrophobic patch (HP). Cyclin A/B RxL-IN-1 inhibits Cyclin A with an IC50 of 0.12 μM. Cyclin A/B RxL-IN-1 demonstrates antitumor efficacy in mouse cell line-derived xenograft (CDX) models. CDK-IN-19 can be used for the study of E2F-driven cancers such as small-cell lung cancer (SCLC) .
    Cyclin A/B RxL-IN-1
  • HY-163626

    DAPK Cancer
    STK17A/B-IN-1 (compound 9) is an orally active, potent, and selective STK17A/B inhibitor with an IC50 of 23 nM against STK17A. STK17A/B-IN-1 can be used for study of cancer .
    STK17A/B-IN-1
  • HY-W765152

    22,23-Dihydro avermectin B1a; epi-Dihydro avermectin B1a

    Parasite Infection
    epi-Ivermectin B1a is a key related substance of Ivermectin (HY-15310), primarily existing as a process-related impurity or potential degradation product in ivermectin-based antiparasitic formulations. epi-Ivermectin B1a can be used for the study of internal/external parasites in cattle .
    epi-Ivermectin B1a
  • HY-177552

    GABA Receptor Chloride Channel Insecticide Infection
    4''-Oxoavermectin B1a is a potentiator targeting GABA (γ-aminobutyric acid) and glutamate-gated chloride channels with insecticidal and acaricidal activities. 4''-Oxoavermectin B1a is promising for research of agricultural pests .
    4''-Oxoavermectin B1a
  • HY-125723

    SL 7810; A-30912 A

    Endogenous Metabolite Fungal Antibiotic Infection
    Echinocandin B (SL 7810) is a lipopeptide antifungal antibiotic. Echinocandin B is produced by Aspergillus nidulans. Echinocandin B inhibits β-1,3-glucan activity, thereby blocking the biosynthesis of fungal cell walls. Echinocandin B exhibits activity against a variety of Aspergillus species .
    Echinocandin B
  • HY-15308R

    Abamectin B1a (Standard)

    Reference Standards Parasite Antibiotic Infection
    Avermectin B1a (Standard) is the analytical standard of Avermectin B1a. This product is intended for research and analytical applications. Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.
    Avermectin B1a (Standard)
  • HY-W012206S1

    Isotope-Labeled Compounds Others
    DL-Metanephrine (hydrochloride) (a,b,b-d3, 98%) is the deuterium labeled DL-Metanephrine (hydrochloride) (a,b,b, 98%) .
    DL-Metanephrine hydrochloride (a,b,b-d3, 98%)
  • HY-N1230

    Allolicoisoflavone B

    Phosphatase Inflammation/Immunology
    Sophoraisoflavone A (Allolicoisoflavone B) is a nature product that could be isolated from Glycyrrhiza inflate. Sophoraisoflavone A is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 value of 0.80 μM. Sophoraisoflavone A can be used in research of inflammation .
    Sophoraisoflavone A
  • HY-139623

    Androgen Receptor Cancer
    A4B17 is an androgen receptor N-terminal inhibitor for researching androgen-responsive prostate cancer.
    A4B17
  • HY-W783297

    Parasite Infection
    8a-OH-Avermectin B1a is a key primary monooxygenated degradate generated during the photodegradation of Avermectin B1a (HY-15308). 8a-OH-Avermectin B1a can be used for the study of antiparasitic infection .
    8a-OH-Avermectin B1a
  • HY-137584

    1a,1b-Dihomo PGE1

    Prostaglandin Receptor Cardiovascular Disease
    1a,1b-Dihomo prostaglandin E1 (1a,1b-Dihomo PGE1) is an E1-type prostaglandin. 1a,1b-Dihomo prostaglandin E1 can be used for research on platelet aggregation .
    1a,1b-Dihomo prostaglandin E1
  • HY-173054

    Bacterial Infection
    FtsZ-IN-12 (Compound 16e) is the inhibitor for filamentous temperature-sensitive mutant Z (FtsZ) that promotes the polymerization of FtsZ protein, inhibits its GTPase activity, thereby interfering with bacterial cell division process. FtsZ-IN-12 exhibits boardspectrum antibacterial activity that inhibits B. subtilis ATCC9372, B. pumilus CMCC63202, S. aureus ATCC25923, E. coli BW25113 and A. baumannii ATCC19606 with MIC of 0.062-1 μg/mL. FtsZ-IN-12 inhibits the formation of bacterial biofilms and exhibits a clearing effect on mature biofilms. FtsZ-IN-12 exhibits bactericidal activity without hemolytic toxicity to mammalian red blood cells (15 mg/kg) .
    FtsZ-IN-12
  • HY-152138

    Bacterial Fungal Infection
    Antituberculosis agent-8 (Compound 9i) is an antitubercular agent with an MIC of 3.53 μM (1.6 μg/mL) against M. tuberculosis H37Rv. Antituberculosis agent-8 also shows good antifungal activity against A. niger with an MIC of 62.50 μM .
    Antituberculosis agent-8
  • HY-N8483

    Parasite Drug Metabolite Infection
    Eprinomectin B1a is a Eprinomectin (HY-12643) metabolite (an antiparasitic compound) .
    Eprinomectin B1a
  • HY-15311R

    Abamectin (Standard); Avermectin B1a-Avermectin B1b mixt. (Standard)

    Reference Standards Parasite Autophagy Apoptosis Reactive Oxygen Species (ROS) Antibiotic Infection Inflammation/Immunology
    Avermectin B1 (Standard) is the analytical standard of Avermectin B1. This product is intended for research and analytical applications. Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy .
    Avermectin B1 (Standard)
  • HY-125637

    Aabomycin A2

    Antibiotic Fungal ATP Synthase Infection
    Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP synthase complex .
    Venturicidin B
  • HY-123686

    Parasite Infection
    Ivermectin B1a monosaccharide is a modified Ivermectin B1a (HY-126937). Ivermectin B1a monosaccharide is an antiparasite agent with a minimum concentration for full activity in Haemonchus contortus larval development of 0.001 μg/mL .
    Ivermectin B1a monosaccharide
  • HY-163636

    A-442b

    Phosphodiesterase (PDE) Ras Cancer
    Deltaflexin3 is a potent PDE6D inhibitor. Deltaflexin3 reduces the signaling of Ras and selectively decreases the KRAS mutant and PDE6D-dependent cancer cells growth .
    Deltaflexin3
  • HY-171896

    Liposome Inflammation/Immunology Cancer
    A28-C6B2 is an ionizable cationic lipid with a pKa of 6.43, and can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vivo. A28-C6B2 can be studied in research for enhancing the selective delivery of mRNA to the spleen, particularly to antigen-presenting cells .
    A28-C6B2
  • HY-N6013R

    Reference Standards Proteasome MMP Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Fungal Bacterial Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Aloin (mixture of A&B) (Standard) is the analytical standard of Aloin (mixture of A&B) (HY-N6013). This product is intended for research and analytical applications. Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .
    Aloin (mixture of A&B) (Standard)
  • HY-P11246

    RXFP Receptor Metabolic Disease
    A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective RXFP4 agonist with a Ki value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (Ki = 602.56 nM) and an inhibitory effect on cAMP (EC50) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC50 of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation .
    A13:B7-24-GG
  • HY-19487A

    Ribocil S enantiomer; ent-Ribocil A

    Bacterial Infection
    Ribocil-B is the active S-isomer of ribocil which can inhibit flavin mononucleotide (FMN) with a KD of 6.6 nM.
    Ribocil B
  • HY-RS12496

    Small Interfering RNA (siRNA) Others

    Scd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Scd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Scd1 Mouse Pre-designed siRNA Set A
    Scd1 Mouse Pre-designed siRNA Set A
  • HY-172212

    Insecticide Reactive Oxygen Species (ROS) Infection
    SDH-IN-23 (Compound B21) is an SDH inhibitor. SDH-IN-23 exhibits excellent nematicidal activity. SDH-IN-23 can inhibit the feeding, reproduction, and embryonic development of nematodes. Meanwhile, SDH-IN-23 exerts a lethal effect on nematodes by triggering oxidative stress, causing intestinal damage, and inhibiting SDH, among other mechanisms .
    SDH-IN-23
  • HY-P0135

    Bacterial Infection
    Penta lysine is an antibacterial agent, that inhibits E. coli, A. baumannii, P. aeruginos, S. aureus, and B. subtilis, with MIC of 1.1-18 μM .
    Penta lysine
  • HY-147999

    Bacterial Fungal Cytochrome P450 Infection
    GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform .
    GlcN-6-P Synthase-IN-1
  • HY-121180

    Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    A-58365B is an Angiotensin-converting Enzyme (ACE) inhibitor. A-58365B has antihypertensive effects .
    A-58365B
  • HY-117568

    Calcium Channel Cardiovascular Disease
    A-80b is a pyridazino[4,5-b]indole derivate. A 80b showsantihypertensive activity and can be used for study of Arterial hypertension .
    A-80b
  • HY-122076

    Antibiotic Bacterial Fungal Infection
    A-26771B is an antibiotic can be obtained from Penicillium turbatum. A-26771B exhibits moderate antimicrobial activity against Gram-positive bacteria, mycoplasma, and fungi. A-26771B also inhibits potassium-dependent ATPase in rat liver mitochondria .
    A-26771B
  • HY-N6174

    (+)-Heronapyrrole B; 16-O-Demethylheronapyrrole A

    Bacterial Infection
    Heronapyrrole B ((+)-Heronapyrrole B) is a Gram-positive-selective antibacterial agent (IC50=0.6-1.1 μM against Staphylococcus aureus ATCC9144). Heronapyrrole B is promising for research of bacterial infections and antibiotics .
    Heronapyrrole B
  • HY-117442

    Sirtuin Cancer
    A2B57 is a selective inhibitor for SIRT 2 with an IC50 of 6.3 µM .
    A2B57
  • HY-Z8942

    Insecticide Parasite Chloride Channel Infection
    Avermectin B2a is an insecticide targeting glutamate-gated chloride channels (GluCls). Avermectin B2a causes hyperpolarization of nematode/insect neurons and subsequent paralysis/death. Avermectin B2a is promising for research of agricultural pests .
    Avermectin B2a
  • HY-119889

    Sirtuin Neurological Disease
    A1B11 is a selective SIRT inhibitor (SIRT2:IC50=5.3 μM) that can be used in the study of neurodegenerative diseases .
    A1B11
  • HY-125490

    Debromoshermilamine A

    Others Cancer
    Shermilamine B, a pyridoacridine alkaloid, exhibits potent anticancer activity in multiple myeloma cell lines .
    Shermilamine B
  • HY-131626

    1a,1b-Dihomo PGE2

    COX Metabolic Disease
    1a,1b-Dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid. 1a,1b-Dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid. This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
    1a,1b-Dihomo prostaglandin E2

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