PEX5 Antibody (YA8286)(PBS only)
(Synonyms: PBD2A; PBD2B; PTS1-BP; PTS1R; PXR1; RCDP5)PEX5 Antibody (YA8286) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PEX5.
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Host:
Mouse
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Isotype:
IgG
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Application:
ICC/IF, FC
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Reactivity :
Human, Dog, Rat, Monkey, Mouse
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
PEX5 Antibody (YA8286) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PEX5.
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Host Mouse
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Species ReactivityHuman, Dog, Rat, Monkey, Mouse
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Calculated Molecular Weight Predicted band size: 69.7 kDa
Full length human recombinant protein of human PEX5 produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PEX5 receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle |In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 |Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].
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Subcellular Localization
Cytoplasm, cytosol,Peroxisome matrix
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Expression
Tissue_Specificity: Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas -
Isoforms & Post-Translational Modification
P50542 has four isomers: P50542-1: 70865 Da (predicted); P50542-2: 66830 Da (predicted); P50542-3: 69872 Da (predicted); P50542-4: 72291 Da (predicted).
Monoubiquitinated at Cys-11 by PEX2 during PEX5 passage through the retrotranslocation channel (By similarity)丨Phosphorylated at Ser-141 by ATM in response to reactive oxygen species (ROS), promoting monoubiquitination at Lys-209 and induction of pexophagy -
Subunit
Interacts (via WxxxF/Y and LVxEF motifs) with PEX14; promoting translocation through the PEX13-PEX14 docking complex (PubMed:11438541, PubMed:19197237, PubMed:24235149, PubMed:24662292, PubMed:28765278)
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SwissProt ID
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Synonyms
PBD2A; PBD2B; PTS1-BP; PTS1R; PXR1; RCDP5
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