Patched/PTCH1 Antibody (YA6714)

Cat. No.: HY-P87021: Data Sheet COA
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Patched/PTCH1 Antibody (YA6714) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Patched/PTCH1.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Patched/PTCH1 Antibody (YA6714) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Patched/PTCH1.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 161 kDa

Species Reactivity

Human

SwissProt ID

Q13635

Gene ID

5727 [NCBI]

Immunogen

Recombinant protein within human PTCH1 aa 122-436 / 1,447.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis

Subcellular Localization：Cell membrane

Expression：
Tissue_Specificity: In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin

Isoforms & Post-Translational Modification：Q13635 has four isomers: Q13635-1: 160545 Da (predicted); Q13635-2: 161038 Da (predicted); Q13635-3: 153853 Da (predicted); Q13635-4: 144356 Da (predicted).
Glycosylation is necessary for SHH binding丨In the absence of Hh ligands, ubiquitination by ITCH at Lys-1426 promotes endocytosis and both proteasomal and lysosomal degradation

Subunit：Interacts with SNX17 (PubMed:15769472)

RRID

AB_3719249

Synonyms

A230106A15Rik antibody; BCNS antibody; FLJ26746 antibody; FLJ42602 antibody; Holoprosencephaly 7 antibody; HPE7 antibody; mes antibody; NBCCS antibody; OTTHUMP00000021709 antibody; OTTHUMP00000021710 antibody; A230106A15Rik antibody; BCNS antibody; FLJ26746 antibody; FLJ42602 antibody; Holoprosencephaly 7 antibody; HPE7 antibody; mes antibody; NBCCS antibody; OTTHUMP00000021709 antibody; OTTHUMP00000021710 antibody; Patched antibody; Patched (Drosophila) homolog antibody; Patched 1 antibody; Patched homolog (Drosophila) antibody; Patched homolog 1 (Drosophila) antibody; Patched homolog 1 antibody; Patched protein homolog 1 antibody; Protein patched homolog 1 antibody; PTC antibody; PTC1 antibody; PTC1_HUMAN antibody; PTCH antibody; PTCH protein +12b antibody; PTCH protein +4' antibody; PTCH protein -10 antibody; PTCH protein antibody; ptch1 antibody; PTCH1 protein antibody; PTCH11 antibody; Ptch2 antibody;

Documentation

Select Batch:

Data Sheet (231 KB) SDS (253 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)