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Patched/PTCH1 Antibody (YA6714)

(Synonyms: A230106A15Rik antibody; BCNS antibody; FLJ26746 antibody; FLJ42602 antibody; Holoprosencephaly 7 antibody; HPE7 antibody; mes antibody; NBCCS antibody; OTTHUMP00000021709 antibody; OTTHUMP00000021710 antibody; A230106A15Rik antibody; BCNS antibody; FLJ26746 antibody; FLJ42602 antibody; Holoprosencephaly 7 antibody; HPE7 antibody; mes antibody; NBCCS antibody; OTTHUMP00000021709 antibody; OTTHUMP00000021710 antibody; Patched antibody; Patched (Drosophila) homolog antibody; Patched 1 antibody; Patched homolog (Drosophila) antibody; Patched homolog 1 (Drosophila) antibody; Patched homolog 1 antibody; Patched protein homolog 1 antibody; Protein patched homolog 1 antibody; PTC antibody; PTC1 antibody; PTC1_HUMAN antibody; PTCH antibody; PTCH protein +12b antibody; PTCH protein +4' antibody; PTCH protein -10 antibody; PTCH protein antibody; ptch1 antibody; PTCH1 protein antibody; PTCH11 antibody; Ptch2 antibody; )

Patched/PTCH1 Antibody (YA6714) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Patched/PTCH1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • Patched/PTCH1 Antibody (YA6714) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:10000

Product Details

Description

Patched/PTCH1 Antibody (YA6714) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Patched/PTCH1.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 161 kDa
Immunogen

Recombinant protein within human PTCH1 aa 122-436 / 1,447.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3719249

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Patched/PTCH1 acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis

  • Subcellular Localization

    Cell membrane

  • Expression


    Tissue_Specificity: In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin

  • Isoforms & Post-Translational Modification

    Q13635 has four isomers: Q13635-1: 160545 Da (predicted); Q13635-2: 161038 Da (predicted); Q13635-3: 153853 Da (predicted); Q13635-4: 144356 Da (predicted).
    Glycosylation is necessary for SHH binding丨In the absence of Hh ligands, ubiquitination by ITCH at Lys-1426 promotes endocytosis and both proteasomal and lysosomal degradation

  • Subunit

    Interacts with SNX17 (PubMed:15769472)

  • SwissProt ID

    Q13635

  • Gene ID
    5727 [NCBI]
  • Synonyms

    A230106A15Rik antibody; BCNS antibody; FLJ26746 antibody; FLJ42602 antibody; Holoprosencephaly 7 antibody; HPE7 antibody; mes antibody; NBCCS antibody; OTTHUMP00000021709 antibody; OTTHUMP00000021710 antibody; A230106A15Rik antibody; BCNS antibody; FLJ26746 antibody; FLJ42602 antibody; Holoprosencephaly 7 antibody; HPE7 antibody; mes antibody; NBCCS antibody; OTTHUMP00000021709 antibody; OTTHUMP00000021710 antibody; Patched antibody; Patched (Drosophila) homolog antibody; Patched 1 antibody; Patched homolog (Drosophila) antibody; Patched homolog 1 (Drosophila) antibody; Patched homolog 1 antibody; Patched protein homolog 1 antibody; Protein patched homolog 1 antibody; PTC antibody; PTC1 antibody; PTC1_HUMAN antibody; PTCH antibody; PTCH protein +12b antibody; PTCH protein +4' antibody; PTCH protein -10 antibody; PTCH protein antibody; ptch1 antibody; PTCH1 protein antibody; PTCH11 antibody; Ptch2 antibody;

Patched/PTCH1 Antibody (YA6714) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • Patched/PTCH1 Antibody (YA6714) Product Image