MLANA Protein, Human (His, B2M)

The MLANA protein is essential in melanosome biosynthesis, ensuring the stability of GPR143, and plays a key role in the expression, stability, transport, and processing of the melanocyte protein PMEL. Its interaction with PMEL and GPR143 highlights its integral role in the complex network required for second-stage melanosome formation. MLANA Protein, Human (His, B2M) is the recombinant human-derived MLANA protein, expressed by E. coli , with N-His, B2M labeled tag.

The MLANA protein is integral to melanosome biogenesis, ensuring the stability of GPR143 and playing a crucial role in the expression, stability, trafficking, and processing of the melanocyte protein PMEL. Its involvement in these processes is essential for the formation of stage II melanosomes. MLANA interacts with both PMEL and GPR143, establishing its role in the intricate network of protein interactions necessary for melanosome development. The coordination of these interactions underscores the significance of MLANA in melanocyte biology and the biogenesis of melanosomes.

Human

E. coli

N-His;B2M

Q16655 (M1-P118)

2315  [NCBI]

Full Length

MPREDAHFIYGYPKKGHGHSYTTAEEAAGIGILTVILGVLLLIGCWYCRRRNGYRALMDKSLHVGTQCALTRRCPQEGFDHRDSKVSLQEKNCEPVVPNAPPAYEKLSAEQSPPPYSP

Approximately 30 kDa

≥ 90%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized after extensive dialysis against solution in PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.