MLANA - melan-A Gene
Also Known as MART1; MART-1
Species: Homo sapiens
About MLANA
This gene has 5 transcripts (splice variants) and 148 orthologues. Biased expression in skin (RPKM 15.6) and colon (RPKM 0.2).
Summary
Located in endoplasmic reticulum membrane; melanosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
MLANA Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_005511.2 | NP_005502.1 | melanoma antigen recognized by T-cells 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15695812 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in Golgi apparatus |
IDA
IDA: Inferred from direct assay
|
12191019 | GOA |
| located in endoplasmic reticulum membrane |
IDA
IDA: Inferred from direct assay
|
15695812 | GOA |
| located in melanosome |
IDA
IDA: Inferred from direct assay
|
15695812 | GOA |
| located in trans-Golgi network |
IDA
IDA: Inferred from direct assay
|
12191019 | GOA |
MLANA Protein Structure
MLANA: Protein melan-A (2 - 118)
- 0
- 100
- 118 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
melanoma antigen recognized by T-cells 1 |
|
MLANA Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
MLANA | Q16655 | EPN2 | Homo sapiens | O95208-2 | 32296183 | |
|
Intra
|
MLANA | Q16655 | EPN2 | Homo sapiens | O95208-2 | 32296183 | |
|
Intra
|
MLANA | Q16655 | ITCH | Homo sapiens | Q96J02 | 20491914 | |
|
Intra
|
MLANA | Q16655 | NEDD4 | Homo sapiens | P46934 | 20491914 |
Recombinant MLANA Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71544 | MLANA Protein, Human (His, B2M) | Q16655 (M1-P118) | ≥ 90%, as determined by reducing SDS-PAGE. |
MLANA Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83295 | Melan-A Antibody (YA3040) | WB, IHC-P, ICC/IF, FC | Human |
| HY-P85918 | Melan-A Antibody (YA5610) | IHC-P, WB, ICC/IF, ELISA | Human |
| HY-P86022 | Melan-A Antibody (YA5714) | IHC-P, ELISA | Human |
| HY-P86451 | Melan-A Antibody (YA6143) | WB, IHC-P, ICC/IF, ELISA | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Melanoma In Congenital Melanocytic Nevus |
|
|
| Angiomyolipoma |
|
|
| Juvenile Xanthogranuloma |
|
|
| Granular Cell Tumor |
|
|
| Perivascular Epithelioid Cell Tumor |
|
|
| Melanoma |
|
|
| Epithelioid Type Angiomyolipoma |
|
|
| Malignant Spindle Cell Melanoma |
|
|
| Central Nervous System Melanocytic Neoplasm |
|
|
| Melanoacanthoma |
|
|
| Epithelioid Cell Melanoma |
|
|
| Hepatic Angiomyolipoma |
|
|
| Meningeal Melanomatosis |
|
|
| Gallbladder Melanoma |
|
|
| Conjunctival Nevus |
|
|
| Balloon Cell Malignant Melanoma |
|
|
| Spinal Cord Melanoma |
|
|
| Perivascular Tumor |
|
|
| Diffuse Meningeal Melanocytosis |
|
|
| Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1 |
|
|
| Meningeal Melanoma |
|
|
| Malignant Leptomeningeal Tumor |
|
|
| Melanomatosis |
|
|
| Infiltrating Angiolipoma |
|
|
| Nodular Malignant Melanoma |
|
|
| Meningeal Melanocytoma |
|
|
| Penis Sarcoma |
|
|
| Microphthalmia |
|
|
| Ovarian Melanoma |
|
|
| Pigmented Basal Cell Carcinoma |
|
|
| Adrenal Carcinoma |
|
|
| Melanotic Neurilemmoma |
|
|
| Ovarian Cystic Teratoma |
|
|
| Malignant Anus Melanoma |
|
|
| Conjunctival Pigmentation |
|
|
| Sarcomatoid Squamous Cell Skin Carcinoma |
|
|
| Epithelioid Malignant Peripheral Nerve Sheath Tumor |
|
|
| Cervical Serous Adenocarcinoma |
|
|
| Acral Lentiginous Melanoma |
|
|
| Neurofibroma |
|
|
| Malignant Choroid Melanoma |
|
|
| Uterus Perivascular Epithelioid Cell Tumor |
|
|
| Adrenal Cortical Adenoma |
|
|
| Keratosis, Seborrheic |
|
|
| Amelanotic Melanoma |
|
|
| Choroid Cancer |
|
|
| Mature Teratoma Of The Ovary |
|
|
| Sebaceous Adenocarcinoma |
|
|
| Ocular Albinism |
|
|
| Melanoma, Uveal |
|
|
| Sensory Organ Benign Neoplasm |
|
|
| Castleman Disease |
|
|
| Conventional Leiomyosarcoma |
|
|
| Anal Canal Paget'S Disease |
|
|
| Malignant Skin Fibrous Histiocytoma |
|
|
| Malignant Dermis Tumor |
|
|
| Mucosal Melanoma |
|
|
| Large Cell Acanthoma |
|
|
| Kidney Angiomyolipoma |
|
|
| Acanthoma |
|
|
| Malignant Conjunctival Melanoma |
|
|
| Large Congenital Melanocytic Nevus |
|
|
| Leiomyosarcoma |
|
|
| Epithelioid Leiomyosarcoma |
|
|
| Conjunctival Cancer |
|
|
| Borst-Jadassohn Intraepidermal Carcinoma |
|
|
| Retinal Melanoma |
|
|
| Vagina Leiomyosarcoma |
|
|
| Ureter Leiomyoma |
|
|
| Malignant Breast Melanoma |
|
|
| Vulvar Melanoma |
|
|
| Tuberous Sclerosis |
|
|
| Paraganglioma |
|
|
| Mesenchymal Cell Neoplasm |
|
|
| Esophagus Melanoma |
|
|
| Cutaneous Leiomyosarcoma |
|
|
| Malignant Granular Cell Myoblastoma |
|
|
| Ovarian Wilms' Cancer |
|
|
| Adult Type Testicular Granulosa Cell Tumor |
|
|
| Glomangiosarcoma |
|
|
| Ocular Cancer |
|
|
| Benign Perivascular Tumor |
|
|
| Clear Cell Sarcoma |
|
|
| Glomangioma |
|
|
| Ovarian Sex-Cord Stromal Tumor |
|
|
| Cutaneous Fibrous Histiocytoma |
|
|
| Skin Carcinoma |
|
|
| Salpingitis Isthmica Nodosa |
|
|
| Vulval Paget'S Disease |
|
|
| Pelvic Lipomatosis |
|
|
| Vascular Cancer |
|
|
| Angiolipoma |
|
|
| Sarcomatoid Renal Cell Carcinoma |
|
|
| Skin Sarcoma |
|
|
| Ciliary Body Cancer |
|
|
| Retroperitoneal Sarcoma |
|
|
| Kidney Benign Neoplasm |
|
|
| Melanotic Neuroectodermal Tumor |
|
|
| Paget Disease, Extramammary |
|
|
| Fibrous Histiocytoma |
|
|
| Malignant Triton Tumor |
|
|
| Connective Tissue Benign Neoplasm |
|
|
| Testicular Fibroma |
|
|
| Spitzoid Melanoma |
|
|
| Internal Hemorrhoid |
|
|
| Small Intestine Leiomyosarcoma |
|
|
| Ovary Leiomyosarcoma |
|
|
| Mongolian Spot |
|
|
| Ocular Melanoma |
|
|
| Sex Cord-Gonadal Stromal Tumor |
|
|
| Adrenal Cortex Disease |
|
|
| Luteoma |
|
|
| Bizarre Leiomyoma |
|
|
| Histiocytic And Dendritic Cell Cancer |
|
|
| Malignant Olfactory Nerve Neoplasm |
|
|
| Testicular Cancer |
|
|
| Alveolar Soft Part Sarcoma |
|
|
| Myofibroma |
|
|
| Intravascular Fasciitis |
|
|
| Hemorrhoid |
|
|
| Solitary Fibrous Tumor/Hemangiopericytoma |
|
|
| Testicular Granulosa Cell Tumor |
|
|
| Juvenile Type Testicular Granulosa Cell Tumor |
|
|
| Vulvar Leiomyosarcoma |
|
|
| Lipomatosis, Multiple |
|
|
| Cranial Nerve Malignant Neoplasm |
|
|
| Endometrial Stromal Tumor |
|
|
| Skin Benign Neoplasm |
|
|
| Respiratory System Benign Neoplasm |
|
|
| Carney Complex Variant |
|
|
| Muscle Cancer |
|
|
| Dermatofibrosarcoma Protuberans |
|
|
| Neurilemmoma |
|
|
| Small Intestine Leiomyoma |
|
|
| Skin Melanoma |
|
|
| Sarcoid Meningitis |
|
|
| Sarcomatoid Transitional Cell Carcinoma |
|
|
| Actinic Keratosis |
|
|
| Well-Differentiated Liposarcoma |
|
|
| Anal Paget'S Disease |
|
|
| Adrenal Gland Disease |
|
|
| Spindle Cell Sarcoma |
|
|
| Adrenal Cortical Carcinoma |
|
|
| Hard Palate Cancer |
|
|
| Cervix Melanoma |
|
|
| Skeletal Muscle Cancer |
|
|
| Endometrial Stromal Sarcoma |
|
|
| Schwannoma Of Twelfth Cranial Nerve |
|
|
| Hypoglossal Nerve Disease |
|
|
| Chondrosarcoma, Extraskeletal Myxoid |
|
|
| Orbit Rhabdomyosarcoma |
|
|
| Inflammatory Myofibroblastic Tumor |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Vagina Sarcoma |
|
|
| Laryngeal Small Cell Carcinoma |
|
|
| Barre-Lieou Syndrome |
|
|
| Melanoma, Cutaneous Malignant 1 |
|
|
| Skin Disease |
|
|
| Meningioma, Familial |
|
|
| Wilms Tumor 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | MLANA | VGNC | VGNC:31494 |
| Rattus norvegicus | MLANA | RGD | RGD:1306525 |
| Mus musculus | MLANA | MGD | MGI:108454 |
| Canis familiaris | MLANA | VGNC | VGNC:43254 |
| Others | MLANA | NCBI |