IL24 Antibody (YA7890)
(Synonyms: C49A; FISP; IL10B; MDA7; MOB5; ST16)IL24 Antibody (YA7890) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL24.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:2000-2500 |
Product Details
IL24 Antibody (YA7890) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL24.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 18.4 kDa
Human recombinant protein fragment corresponding to amino acids 52-206 of human IL24 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IL24 multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2[1][2][3][4].
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Up-regulated in melanoma cells induced to terminally differentiate
Induction: Upon influenza virus infection -
Isoforms & Post-Translational Modification
Q13007 has four isomers: Q13007-1: 23825 Da (predicted); Q13007-2: 23912 Da (predicted); Q13007-3: 17751 Da (predicted); Q13007-4: 7347 Da (predicted).
Glycosylated丨Ubiquitination at Lys-122 promotes proteasomal degradation -
SwissProt ID
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Synonyms
C49A; FISP; IL10B; MDA7; MOB5; ST16
Documentation
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