IL24 Antibody (YA7890)

Cat. No.: HY-P88206: Data Sheet User Guide for Antibodies
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IL24 Antibody (YA7890) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL24.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

IL24 Antibody (YA7890) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL24.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 18.4 kDa

Species Reactivity

Human

SwissProt ID

Q13007

Immunogen

Human recombinant protein fragment corresponding to amino acids 52-206 of human IL24 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:2000-2500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity)

Subcellular Localization：Secreted

Expression：
Tissue_Specificity: Up-regulated in melanoma cells induced to terminally differentiate
Induction: Upon influenza virus infection

Isoforms & Post-Translational Modification：Q13007 has four isomers: Q13007-1: 23825 Da (predicted); Q13007-2: 23912 Da (predicted); Q13007-3: 17751 Da (predicted); Q13007-4: 7347 Da (predicted).
Glycosylated丨Ubiquitination at Lys-122 promotes proteasomal degradation

Synonyms

C49A; FISP; IL10B; MDA7; MOB5; ST16

Documentation

User Guide for Antibodies (1077 KB)