MAO-A/B-IN-4
MAO-A/B-IN-4 is an orally active MAO-A/B inhibitor, with IC50 values of 51.3 μM and 47.0 μM, respectively. MAO-A/B-IN-4 exhibits potent activity against S. aureus, MSSA, MRSA, LRSA, and LREFa. MAO-A/B-IN-4 demonstrates potent antibacterial efficacy in a mouse model of LRSA peritonitis infection. MAO-A/B-IN-4 can be used for the study of bacterial infections.
For research use only. We do not sell to patients.
- Formula: C22H21F2N7O3
- Molecular Weight:469.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MAO-A/B-IN-4 (Compound D13) exhibits potent antibacterial activity against S. aureus, MSSA, MRSA, LRSA, and LREFa, with MIC values of < 1 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LRSA20-2 bacterial suspension (0.5 mL, 3.5×107 CFU/mL) was intraperitoneally injected into ICR mice to construct the LRSA peritonitis infection model[1]
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Dosage:2.5, 10, 40 mg/kg
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Administration:i.g., administration time: 5 min and 6 h post-infection
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Result:Achieved survival rates of 0%, 12.5%, and 100% at doses of 2.5, 10, and 40 mg/kg, respectively.
Showed no significant acute toxicity.
Chemical Information
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Molecular Weight 469.44
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Formula C22H21F2N7O3
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SMILES
O=C1O[C@H](CN1C2=CC(F)=C(C(F)=C2)C3=CN=C(C=C3)/C=N/N4CCOCC4)CN5C=CN=N5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Duan M, et al. Multiparameter Optimization of Broad-Spectrum Antibacterial Activity, ADMET Properties, and MAO-A/B Inhibition of Novel Biaryloxazolidinone-Hydrazone Derivatives: Identification of a Lead with In Vivo Efficacy against Linezolid-Resistant Staphylococcus aureus. J Med Chem. 2025 Aug 28;68(16):16958-16988. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-A/B-IN-4 Related Classifications
HY-175723 Related Classifications
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