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HNRNPA2B1 Protein, Human (His-B2M)

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Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (His-B2M) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-6*His, B2M labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: E. coli
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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To place orders, for customer services and technical support, please contact:

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[email protected] [email protected]
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  • Biological Activity
  • Technical Parameters
  • Product Properties
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Biological Activity

Description

Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (His-B2M) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-6*His, B2M labeled tag.

Background

Heterogeneous nuclear ribonucleoproteins A2/B1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Heterogeneous nuclear ribonucleoproteins A2/B1 is RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). Heterogeneous nuclear ribonucleoproteins A2/B1 is associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. Heterogeneous nuclear ribonucleoproteins A2/B1 has distinct nucleic acid binding properties. Heterogeneous nuclear ribonucleoproteins A2/B1 has two repeats of quasi-RRM domains that bind to RNAs. Heterogeneous nuclear ribonucleoproteins A2/B1 has been described to generate two alternatively spliced transcript variants which encode different isoforms[1][2][3][4][5].

Technical Parameters

  • Species Human
  • Source E. coli
  • Tag N-6*His;B2M
  • Accession

    I6L957 (M1-Q249)

  • Gene ID
    /
  • Molecular Construction
    • N-term
    • 6*His-B2M
    • HNRNPA2B1 (M1-Q249)
      Accession # I6L957
    • C-term
  • Protein Length

    Full Length

  • Synonyms

    HNRNPA2B1; HnRNP A2 / HnRNP B1; Prev. HNRPA2B1; IBMPFD2; Heterogeneous Nuclear Ribonucleoproteins A2/B1; HNRPA2; HNRNPA2; HNRPB1; HNRNPB1; SNRPB1; Nuclear Ribonucleoprotein Particle A2 Protein; OPDM2; Epididymis Secretory Sperm Binding Protein; OPMD2; HNR

  • AA Sequence

    MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEDLEVAILEVAPVMEEEEEDMVVEDLDMATRVGATEVVMTTMEEEIMEVEITMILEIITSNLLTTVQ

  • Predicted Molecular Mass

    42.4 kDa

  • Purity

    ≥ 90%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of 10 mM Tris-HCl, 1 mM EDTA, 6% trehalose, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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