HNRNPA2B1 Protein, Human (GST)
Based on 1 Customer Validation
Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (GST) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-GST labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (GST) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-GST labeled tag.
Background
Heterogeneous nuclear ribonucleoproteins A2/B1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Heterogeneous nuclear ribonucleoproteins A2/B1 is RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). Heterogeneous nuclear ribonucleoproteins A2/B1 is associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. Heterogeneous nuclear ribonucleoproteins A2/B1 has distinct nucleic acid binding properties. Heterogeneous nuclear ribonucleoproteins A2/B1 has two repeats of quasi-RRM domains that bind to RNAs. Heterogeneous nuclear ribonucleoproteins A2/B1 has been described to generate two alternatively spliced transcript variants which encode different isoforms[1][2][3][4][5].
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Human
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Source E. coli
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Tag N-GST
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Accession
I6L957 (M1-Q249)
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Gene ID/
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Molecular Construction
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N-term
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GST
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HNRNPA2B1 (M1-Q249)
Accession # I6L957 -
C-term
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Protein Length
Full Length
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Synonyms
HNRNPA2B1; HnRNP A2 / HnRNP B1; Prev. HNRPA2B1; IBMPFD2; Heterogeneous Nuclear Ribonucleoproteins A2/B1; HNRPA2; HNRNPA2; HNRPB1; HNRNPB1; SNRPB1; Nuclear Ribonucleoprotein Particle A2 Protein; OPDM2; Epididymis Secretory Sperm Binding Protein; OPMD2; HNR
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AA Sequence
MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEDLEVAILEVAPVMEEEEEDMVVEDLDMATRVGATEVVMTTMEEEIMEVEITMILEIITSNLLTTVQ
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Molecular Weight
Approximately 58-64 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (263 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Huang Y, et al. A2/B1 Promotes NRF2 mRNA Stability and Inhibits Ferroptosis and Cell Proliferation in Breast Cancer Cells. Biomed Res Int. 2023 Apr 14;2023:2620738. [Content Brief]
[2]. Ruffenach G, et al. HNRNPA2B1: RNA-Binding Protein That Orchestrates Smooth Muscle Cell Phenotype in Pulmonary Arterial Hypertension. Circulation. 2022 Oct 18;146(16):1243-1258. [Content Brief]
[3]. Chen C, et al. HNRNPA2B1 Demonstrates Diagnostic and Prognostic Values Based on Pan-Cancer Analyses. Comput Math Methods Med. 2022 Apr 27;2022:9867660. [Content Brief]
[4]. Kim HJ, et al. Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy. Nat Commun. 2022 Apr 28;13(1):2306. [Content Brief]
[5]. Petri BJ, et al. HNRNPA2B1 regulates tamoxifen- and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells. Cancer Lett. 2021 Oct 10;518:152-168. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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