2. Concanamycin A

Concanamycin A  (Synonyms: Antibiotic X 4357B; Folimycin; X 4357B)

Cat. No.: HY-N1724 Purity: ≥99.0%
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Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research-.

For research use only. We do not sell to patients.

Concanamycin A Chemical Structure

Concanamycin A Chemical Structure

CAS No. : 80890-47-7

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25 μg USD 149 In-stock
50 μg USD 240 In-stock

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Based on 9 publication(s) in Google Scholar

Concanamycin A Related Antibodies

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Description

Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5].

IC50 & Target

Vacuolar type H+-ATPase[1]
In Vitro

Concanamycin A can come from S. diastatochromogenes, as a microbial metabolite with immunomodulatory activity[1].
? Concanamycin A (100 nM; 0-20 h) results DNA fragmentation in CD4+ and selectively induces CD8+ T cells rapid cell death between normal and the immunized mice source, while CD8+ population in mice immunized is more sensitive[2].
? Concanamycin A (3-50 nM; 16 h) inhibits LPS-induced NO production in elicited peritoneal macrophages, but (25 nM; 7 h) doesn’t inhibit LPS-induced TNF-α production[3].
? Concanamycin A (0.01 nM-1 nM) inhibits the acidification of rat liver lysosomes (IC50 =0.061 nM), and inhibits oleate incorporation into cholesteryl ester (IC50 =14 nM)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Concanamycin A Related Antibodies

Cell Viability Assay[2]

Cell Line: CD8+ cytotoxic T lymphocytes (CTLs)
Concentration: 100 nM
Incubation Time: 0, 4, 8, 12, 16, 20 hours
Result: Induced rapid cell death instead of apoptosis at 20 h, without observed condensed nuclei.
In Vivo

Concanamycin A (15 mg/kg; i.v.; 0, 10 or 24 h prior to sacrifice) induces T cell-mediated hepatitis in mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild type mice[5]
Dosage: 15 mg/kg
Administration: Intravenous injection 0, 10 or 24 h prior to sacrifice
Result: Resulted significant liver injury as demonstrated by serum transaminase levels, inflammatory cell infiltrate, hepatocyte apoptosis, and expression of several cytokines including interleukin 4 (IL4) and interferon gamma (IFNγ) at 10 h and 24 h following administration.
Molecular Weight

866.09

Formula

C46H75NO14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H]([C@@](C[C@H]1O[C@@](O[C@H](C)[C@H]2OC(N)=O)([H])C[C@H]2O)(O[C@H](/C=C/C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]([C@@H](O)[C@H]3CC)C)=O)([H])[C@H](/C=C/C=C(C[C@H]([C@@H]3O)C)/C)OC)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 10 mg/mL (11.55 mM; Need ultrasonic and warming)

DMSO : ≥ 10 mg/mL (11.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1546 mL 5.7731 mL 11.5461 mL
5 mM 0.2309 mL 1.1546 mL 2.3092 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (248 KB) RP-HPLC (891 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol / DMSO 1 mM 1.1546 mL 5.7731 mL 11.5461 mL 28.8654 mL
5 mM 0.2309 mL 1.1546 mL 2.3092 mL 5.7731 mL
10 mM 0.1155 mL 0.5773 mL 1.1546 mL 2.8865 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Concanamycin A80890-47-7Antibiotic X 4357B Folimycin X 4357BInhibitorinhibitorinhibit

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