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Cat. No.: HY-P11246

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A13:B7-24-GG

A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective RXFP4 agonist with a K_i value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (K_i = 602.56 nM) and an inhibitory effect on cAMP (EC₅₀) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC₅₀ of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation.

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CAS No.: 3057097-31-8
Formule: C₁₄₉H₂₃₆N₄₀O₄₇S₅
Masse moléculaire:3500.03

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

A13:B7-24-GG Chemical Structure

CAS No.: 3057097-31-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Chemical Information

CAS No. 3057097-31-8
Masse moléculaire 3500.03
Formule C₁₄₉H₂₃₆N₄₀O₄₇S₅
Sequence

Chain1:Cys-Thr-Asp-Gly-Ala-Ser-Met-Lys-Asp-Leu-Ser-Ala-Leu-Cys Chain2:Cys-Gly-Leu-Glu-Tyr-Ile-Arg-Thr-Val-Ile-Tyr-Ile-Cys-Gly-Gly-Ser-Arg-Trp (Disulfidebridge:Chain 1 Cys1-Chain 2 Cys1, Chain 1 Cys14-Chain 2 Cys13)
Sequence Shortening

CTDGASMKDLSALC CGLEYIRTVIYICGGSRW (Disulfidebridge:Chain 1 Cys1-Chain 2 Cys1, Chain 1 Cys14-Chain 2 Cys13)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang MD, et al. Homologous Peptide Foldamer Promotes FUS Aggregation and Triggers Cancer Cell Death. J Am Chem Soc. 2024 Oct 23;146(42):28669-28676. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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