2. GPCR/G Protein
  3. RXFP Receptor
  4. A13:B7-24-GG

A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective RXFP4 agonist with a Ki value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (Ki = 602.56 nM) and an inhibitory effect on cAMP (EC50) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC50 of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation.

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Custom Peptide Synthesis

A13:B7-24-GG

A13:B7-24-GG Chemical Structure

CAS No. : 3057097-31-8

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A13:B7-24-GG Related Antibodies

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Description

A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective RXFP4 agonist with a Ki value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (Ki = 602.56 nM) and an inhibitory effect on cAMP (EC50) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC50 of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation[1].

Molecular Weight

3500.03

Formula

C149H236N40O47S5
CAS No.
Sequence

Chain1:Cys-Thr-Asp-Gly-Ala-Ser-Met-Lys-Asp-Leu-Ser-Ala-Leu-Cys Chain2:Cys-Gly-Leu-Glu-Tyr-Ile-Arg-Thr-Val-Ile-Tyr-Ile-Cys-Gly-Gly-Ser-Arg-Trp (Disulfidebridge:Chain 1 Cys1-Chain 2 Cys1, Chain 1 Cys14-Chain 2 Cys13)
Sequence Shortening

CTDGASMKDLSALC CGLEYIRTVIYICGGSRW (Disulfidebridge:Chain 1 Cys1-Chain 2 Cys1, Chain 1 Cys14-Chain 2 Cys13)
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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A13:B7-24-GG Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A13:B7-24-GG3057097-31-8RXFP ReceptorRelaxin family peptideINSL5RXFP4peptide engineeringglycine substitutionreceptor selectivityagonist potencyInhibitorinhibitorinhibit

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