JNK3 Protein, Human

JNK3 is a critical serine/threonine protein kinase in neuronal processes, regulating proliferation, differentiation, migration, and apoptosis. Activation through MAP2K4/MKK4 and MAP2K7/MKK7 leads to phosphorylation of JNK3, which in turn phosphorylates AP-1 components such as JUN and ATF2, thereby regulating AP-1 transcriptional activity. JNK3 Protein, Human is the recombinant human-derived JNK3 protein, expressed by E. coli , with tag free. The total length of JNK3 Protein, Human is 423 a.a., .

JNK3, a serine/threonine-protein kinase, is a key player in diverse neuronal processes, including proliferation, differentiation, migration, and programmed cell death. Activation of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway by extracellular stimuli, such as pro-inflammatory cytokines or physical stress, involves the phosphorylation and activation of JNK3 by dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7. Within this cascade, JNK3 phosphorylates critical transcription factors, particularly components of AP-1 like JUN and ATF2, thereby regulating AP-1 transcriptional activity. JNK3 plays pivotal roles in neuronal apoptosis by modulating signaling pathways, and it phosphorylates the neuronal microtubule regulator STMN2. Additionally, in the regulation of amyloid-beta precursor protein/APP signaling during neuronal differentiation, JNK3 phosphorylates APP. Furthermore, JNK3 contributes to neurite growth in spiral ganglion neurons and phosphorylates the CLOCK-BMAL1 heterodimer, influencing the photic regulation of the circadian clock. Notably, JNK3 phosphorylates JUND, and this phosphorylation is inhibited in the presence of MEN1.

Human

E. coli

Tag Free

P53779 (M1-S423)

5602

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.