CD20/MS4A1 Protein, Dog (HEK293, His, Nanodisc)
CD20/MS4A1 protein-VLP, Dog, a B lymphocyte membrane protein critical for calcium influx and essential for B lymphocyte development, differentiation, and activation. As a component of store-operated calcium (SOC) channels, it promotes calcium influx upon B cell receptor/BCR activation. CD20/MS4A1 Protein, Dog (HEK293, His, Nanodisc) is the recombinant dog-derived CD20/MS4A1 protein, expressed by HEK293, with C-His labeled tag.
- Species: Dog
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
CD20/MS4A1 protein-VLP, Dog, a B lymphocyte membrane protein critical for calcium influx and essential for B lymphocyte development, differentiation, and activation. As a component of store-operated calcium (SOC) channels, it promotes calcium influx upon B cell receptor/BCR activation. CD20/MS4A1 Protein, Dog (HEK293, His, Nanodisc) is the recombinant dog-derived CD20/MS4A1 protein, expressed by HEK293, with C-His labeled tag.
Background
The CD20/MS4A1 Protein-VLP, Dog, serves as a B-lymphocyte-specific membrane protein, pivotal in regulating cellular calcium influx essential for the development, differentiation, and activation of B-lymphocytes. Operating as a store-operated calcium (SOC) channel component, it facilitates calcium influx upon activation by the B-cell receptor/BCR. The protein forms homotetramers, contributing to its structural organization and functional role in calcium signaling. An integral part of the B-cell receptor complex, CD20/MS4A1 Protein-VLP, Dog, interacts specifically with the heavy and light chains of cell surface IgM, representing the antigen-binding components of the BCR. This interaction highlights its crucial role in B-cell activation and underscores its significance in the orchestration of immune responses.
Technical Parameters
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Species Dog
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Source HEK293
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Tag C-His
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Accession
Q3C2E2 (M1-P297)
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Gene ID485430
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Molecular Construction
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N-term
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CD20 (M1-P297)
Accession # Q3C2E2 -
His
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C-term
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Protein Length
Full Length
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Synonyms
MS4A1; CD20 Antigen; Prev. CD20; B-Lymphocyte Cell-Surface Antigen B1; Bp35; B-Lymphocyte Surface Antigen B1; FMC7; CD20 Receptor; B1; LEU-16; Membrane-Spanning 4-Domains, Subfamily A, Member 1; CVID5; Leukocyte Surface Antigen Leu-16; S7; B-Lymphocyte An
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AA Sequence
MTTPRNSMSGTLPVDPMKSPTAMYPVQKIIPKRMPSVVGPTQNFFMRESKTLGAVQIMNGLFHIALGSLLMIHTDVCAPICITMWYPLWGGIMFIISGSLLAAADKNPRKSLVKGKMIMNSLSLFAAISGIIFLIMDIFNITISHFFKMENLNLIKAPMPYVDIHNCDPANPSEKNSLSIQYCGSIRSVFLGVFAVMLIFAFFQKLVTAGIVENEWKKLCSKPKSDVVVLLAAEEKKEQPIETTEEMVELTEIASQPKKEEDIEIIPVQEEEGELEINFAEPPQEQESSPIENDSIP
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Predicted Molecular Mass
35.2 kDa
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Molecular Weight
Approximately 25 kDa & 40 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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