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MYO7A Antibody (YA1665)

(Synonyms: DFNA11; DFNB2; Myo7a; MYU7A; NSRD2; Ush1b)
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Based on 1 Customer Validation

MYO7A Antibody (YA1665) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYO7A.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for MYO7A Antibody (YA1665)
  • MYO7A Antibody (YA1665) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:500-1:1000 1:50-1:200 1:50-1:100

Product Details

Description

MYO7A Antibody (YA1665) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYO7A.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 254 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 254 kDa
Species Reactivity Database
Immunogen

A synthesized peptide derived from human Myosin VIIa aa11-85.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3104016

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for MYO7A Antibody (YA1665)
    Western blot analysis was performed on extracts from Mouse testis (lane 1, 20 μg) using MYO7A Rabbit mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non - fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (beta-Actin, HY-P83730, 1:5000 dilution) were incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti - Rabbit IgG - HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

Background

  • Function

    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing

  • Subcellular Localization

    Cytoplasm; Cytoplasm, cell cortex; Cytoplasm, cytoskeleton; Synapse

  • Expression


    Tissue_specificity:Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain

  • Isoforms & Post-Translational Modification

    Q13402 has 8 isomers: Q13402-1: 254390 Da (predicted); Q13402-2: 250245 Da (predicted); Q13402-3: 138349 Da (predicted); Q13402-4: 138689 Da (predicted); Q13402-5: 240641 Da (predicted); Q13402-6: 250966 Da (predicted); Q13402-7: 249961 Da (predicted); Q13402-8: 249165 Da (predicted).

  • Subunit

    Identified in a complex with USH1C and USH1G (PubMed:21709241). Interacts with MYRIP (PubMed:11964381). Interacts with RPE65 (PubMed:21493626).

  • SwissProt ID

    Q13402

  • Gene ID
    4647 [NCBI]
  • Synonyms

    DFNA11; DFNB2; Myo7a; MYU7A; NSRD2; Ush1b

  • Research Field

    Signal Transduction

MYO7A Antibody (YA1665) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedchemExpress Validation
     Western blot analysis was performed on extracts from Mouse testis (lane 1, 20 μg) using MYO7A Rabbit mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non - fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (beta-Actin, HY-P83730, 1:5000 dilution) were incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti - Rabbit IgG - HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

  • MYO7A Antibody (YA1665) Product Image
    1/16
  • Experimental Validation Results for MYO7A Antibody (YA1665)
  • MYO7A Antibody (YA1665) Product Image
  • Experimental Validation Results for MYO7A Antibody (YA1665)
    1/1
    MedchemExpress Validation
     Western blot analysis was performed on extracts from Mouse testis (lane 1, 20 μg) using MYO7A Rabbit mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non - fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (beta-Actin, HY-P83730, 1:5000 dilution) were incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti - Rabbit IgG - HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.
  • Experimental Validation Results for MYO7A Antibody (YA1665)
  • MYO7A Antibody (YA1665) Product Image
    MedchemExpress Validation

    Western blot analysis was performed on extracts from Mouse testis (lane 1, 20 μg) using MYO7A Rabbit mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non - fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (beta-Actin, HY-P83730, 1:5000 dilution) were incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti - Rabbit IgG - HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

  • MYO7A Antibody (YA1665) Product Image WB