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RNF144B (IBRDC2) Antibody (YA8416)(PBS only)

(Synonyms: bA528A10.3; IBRDC2; p53RFP; PIR2)

RNF144B (IBRDC2) Antibody (YA8416) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RNF144B (IBRDC2).

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • RNF144B (IBRDC2) Antibody (YA8416)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:50-100 1:100

Product Details

Description

RNF144B (IBRDC2) Antibody (YA8416) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RNF144B (IBRDC2).

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 33.5 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 1-256 of human RNF144B produced in E. coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    RNF144B is an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Plays a crucial role in maintaining the genomic stability by controlling the degradation of multiple proteins involved in mitotic progression and DNA damage. Regulates epithelial homeostasis by mediating degradation of CDKN1A and isoform 2 of TP63. Plays a regulatory role in innate immunity by negatively regulating IRF3 activation and IFN-beta production. Mechanistically, inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination independently of its E3 ligase activity. Alternatively, promotes 'Lys-27' and 'Lys-33'-linked ubiquitination of IFIH1/MDA5, promoting selective autophagic degradation of IFIH1/MDA5 to inhibit antiviral response[1][2][3][4].

  • Subcellular Localization

    Mitochondrion membrane,Cytoplasm

  • Expression


    Tissue_Specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis
    Induction: Transcriptionally by TP53 or TP63 (PubMed:23128396, PubMed:38685100). By LPS (PubMed:31509299)

  • Isoforms & Post-Translational Modification

    Q7Z419 has two isomers: Q7Z419-1: 33697 Da (predicted); Q7Z419-2: 23856 Da (predicted).
    Auto-ubiquitinated

  • Subunit

    Interacts with UBE2L3, UBE2L6 and LCMT2, as well as with BAX

  • SwissProt ID

    Q7Z419

  • Synonyms

    bA528A10.3; IBRDC2; p53RFP; PIR2

RNF144B (IBRDC2) Antibody (YA8416)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • RNF144B (IBRDC2) Antibody (YA8416)(PBS only) Product Image
    1/16
  • RNF144B (IBRDC2) Antibody (YA8416)(PBS only) Product Image