ABCB10 Protein, Human (HEK293, Flag, His, N229A)

ABCB10 Protein, Human (HEK293, Flag, His, N229A) is the recombinant human-derived ABCB10, expressed by HEK293, with His, Flag labeled tag.

ABCB10 is an ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix and plays a crucial role in hemoglobin synthesis and antioxidative stress. It participates in the early step of the heme biosynthetic process during the insertion of iron into protoporphyrin IX (PPIX). Additionally, ABCB10 is involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37 (by similar). While ABCB10 likely does not participate in peptide export from mitochondria, it may be involved in the mitochondrial unfolded protein response (UPRmt) signaling pathway.

Human

HEK293

His;Flag

Q9NRK6 (A152-A738, N229A)

23456

Partial

AGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAAAAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.