MAO-A/B-IN-5
MAO-A/B-IN-5 is an orally active MAO-A (IC50 = 73.88 μM) and MAO-B (IC50 = 91.08 μM) inhibitor. MAO-A/B-IN-5 reverses Sodium nitroprusside (SNP) (HY-B0564)-induced cerebral lipid peroxidation (IC50 = 130.2 μM) and protein carbonylation (IC50 = 229.8 μM). MAO-A/B-IN-5 shows dose-dependent and time-dependent antidepressant-like efficacy in mice. MAO-A/B-IN-5 can be used for the study of depressive disorder.
For research use only. We do not sell to patients.
- Formula: C21H20BrNOSe
- Molecular Weight:461.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MAO-A 73.88 μM (IC50) |
MAO-B 91.08 μM (IC50) |
MAO-A/B-IN-5 (Compound 3B) (25-200 μM) significantly inhibits cerebral MAO-A and MAO-B activities in mouse brain tissue, with IC50 values of 73.88 μM for MAO-A and 91.08 μM for MAO-B[1].
MAO-A/B-IN-5 (100-500 μM) reverses sodium nitroprusside (SNP)-induced cerebral lipid peroxidation (IC50 = 130.2 μM) and protein carbonylation (IC50 = 229.8 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MAO-A/B-IN-5 (50-300 mg/kg, , i.g., once, observed for 14 days) causes no mortality, no obvious toxicity signs, and no significant changes in food/water intake, body weight, or organ oxidative damage in female Swiss mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Swiss mice (25-30 g)[1]
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Dosage:0.5, 1, 2.5, 5 mg/kg
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Administration:i.g., once
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Result:Demonstrated dose-dependent antidepressant-like activity in male Swiss mice (30 min post-intragastric administration), with significant effects at doses of 1, 2.5, and 5 mg/kg.
Increased latency to immobility and reduced total immobility time in TST.
Chemical Information
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Molecular Weight 461.25
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Formula C21H20BrNOSe
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SMILES
CC1=CC=C(C(C[N+]2=CC=CC=C2C[Se]C3=CC=CC=C3)=O)C=C1.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-A/B-IN-5 Related Classifications
HY-178149 Related Classifications
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