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Cat. No.: HY-161673

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CDC14A/B-IN-1

CDC14A/B-IN-1 (Compound 15) is an orally available inhibitor of CDC14A/B phosphatases with Ki values ??of 57.4 nM (CDC14A) and 90.0 nM (CDC14B), respectively.

For research use only. We do not sell to patients.

CAS No.: 3048655-03-1
Formula: C₂₁H₁₅F₂O₄P
Molecular Weight:400.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

CDC14A/B-IN-1 Chemical Structure

CAS No.: 3048655-03-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CDC14A/B-IN-1 (Compound 15) is an orally available inhibitor of CDC14A/B phosphatases with Ki values ??of 57.4 nM (CDC14A) and 90.0 nM (CDC14B), respectively^[1].

IC₅₀ & Target

CDC14A/B phosphatases^[1]

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Chemical Information

CAS No. 3048655-03-1
Molecular Weight 400.31
Formula C₂₁H₁₅F₂O₄P
SMILES

FC(F)(P(O)(O)=O)C1=C2C(OC3=C2C=CC=C3)=C(C=C1)C(C4=CC=CC=C4)=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dong J, et al. Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases. J Med Chem. 2024 Jun 13;67(11):8817-8835. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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