METTL7A Antibody (YA8008)

Cat. No.: HY-P88324: Data Sheet User Guide for Antibodies
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METTL7A Antibody (YA8008) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to METTL7A.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

METTL7A Antibody (YA8008) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to METTL7A.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 28.1 kDa

Species Reactivity

Human, Rat

SwissProt ID

Q9H8H3

Immunogen

Human recombinant protein fragment corresponding to amino acids 34-104 of human METTL7A produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:2000-2500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2a

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358)|(Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation

Subcellular Localization：Lipid droplet,Endoplasmic reticulum,Membrane,Microsome,Cytoplasm, cytosol

Expression：
Tissue_Specificity: Expressed in the liver
Induction: Silenced by miR-6807-5p

Isoforms & Post-Translational Modification：Q9H8H3: 244 amino acids, molecular weight 28319 Da.

Subunit：(Microbial infection) Interacts with HCV non-structural protein 4B/NS4B (via C-terminal region); this interaction may promote the recruitment of NS4B in the proximity of lipid droplet

Synonyms

AAM-B

Documentation

User Guide for Antibodies (1077 KB)