METTL7A Antibody (YA8008)
(Synonyms: AAM-B)METTL7A Antibody (YA8008) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to METTL7A.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P
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Reactivity :
Human, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:2000-2500 |
Product Details
METTL7A Antibody (YA8008) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to METTL7A.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Rat
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Calculated Molecular Weight Predicted band size: 28.1 kDa
Human recombinant protein fragment corresponding to amino acids 34-104 of human METTL7A produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
METTL7A is a Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface. Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival. Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles |(Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation[1][2][3][4][5].
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Subcellular Localization
Lipid droplet,Endoplasmic reticulum,Membrane,Microsome,Cytoplasm, cytosol
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Expression
Tissue_Specificity: Expressed in the liver
Induction: Silenced by miR-6807-5p -
Isoforms & Post-Translational Modification
Q9H8H3: 244 amino acids, molecular weight 28319 Da.
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Subunit
(Microbial infection) Interacts with HCV non-structural protein 4B/NS4B (via C-terminal region); this interaction may promote the recruitment of NS4B in the proximity of lipid droplet
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SwissProt ID
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Synonyms
AAM-B
Documentation
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