MAGEA4 Protein, Human (HEK293, His)
MAGEA4 protein critically regulates cell proliferation by inhibiting G1 phase arrest and negatively modulates p53-mediated apoptosis. Its role in controlling key checkpoints emphasizes its impact on cellular homeostasis, suggesting significance in averting aberrant cell growth. MAGEA4 Protein, Human (HEK293, His) is the recombinant human-derived MAGEA4 protein, expressed by HEK293 , with C-10*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
MAGEA4 protein critically regulates cell proliferation by inhibiting G1 phase arrest and negatively modulates p53-mediated apoptosis. Its role in controlling key checkpoints emphasizes its impact on cellular homeostasis, suggesting significance in averting aberrant cell growth. MAGEA4 Protein, Human (HEK293, His) is the recombinant human-derived MAGEA4 protein, expressed by HEK293 , with C-10*His labeled tag.
The MAGEA4 protein plays a crucial role in regulating cell proliferation by inhibiting cell cycle arrest at the G1 phase, as evidenced by studies. Additionally, MAGEA4 exerts a negative regulatory effect on p53-mediated apoptosis, further highlighting its involvement in controlling cellular processes associated with cell cycle progression and apoptotic pathways. These functions underscore the significance of MAGEA4 in modulating key checkpoints that govern cell division and apoptosis, suggesting its potential impact on cellular homeostasis and the avoidance of aberrant cell growth.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-10*His
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Accession
P43358 (M1-V317)
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Molecular Construction
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N-term
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MAGEA4 (M1-V317)
Accession # P43358 -
10*His
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C-term
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Protein Length
Full Length
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Synonyms
MAGEA4; Melanoma Antigen Family A4; Prev. MAGE4; MAGE-41 Antigen; Melanoma-Associated Antigen 4; MAGE-X2 Antigen; CT1.4; MAGE-4 Antigen; MAGE-41; MGC21336; MAGE-X2; CDNA, FLJ94494, Homo Sapiens Melanoma Antigen, Family A, 4 (MAGEA4), MRNA; MAGE4A; Melanom
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AA Sequence
MSSEQKSQHCKPEEGVEAQEEALGLVGAQAPTTEEQEAAVSSSSPLVPGTLEEVPAAESAGPPQSPQGASALPTTISFTCWRQPNEGSSSQEEEGPSTSPDAESLFREALSNKVDELAHFLLRKYRAKELVTKAEMLERVIKNYKRCFPVIFGKASESLKMIFGIDVKEVDPASNTYTLVTCLGLSYDGLLGNNQIFPKTGLLIIVLGTIAMEGDSASEEEIWEELGVMGVYDGREHTVYGEPRKLLTQDWVQENYLEYRQVPGSNPARYEFLWGPRALAETSYVKVLEHVVRVNARVRIAYPSLREAALLEEEEGV
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Predicted Molecular Mass
36.7 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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