MAGEA4 - MAGE family member A4 Gene

Also Known as CT1.4; MAGE4; MAGE4A; MAGE4B; MAGE-41; MAGE-X2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4103

About MAGEA4

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:151,912,474-151,925,170 (from NCBI)

This gene has 18 transcripts (splice variants), 460 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 13.7).

Summary

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each Other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020]

MAGEA4 Products (11)

mRNA	Protein	Name
NM_001011548.1	NP_001011548.1	melanoma-associated antigen 4
NM_001011549.1	NP_001011549.1	melanoma-associated antigen 4
NM_001011550.1	NP_001011550.1	melanoma-associated antigen 4
NM_001386196.1	NP_001373125.1	melanoma-associated antigen 4
NM_001386197.1	NP_001373126.1	melanoma-associated antigen 4
NM_001386198.1	NP_001373127.1	melanoma-associated antigen 4
NM_001386199.1	NP_001373128.1	melanoma-associated antigen 4
NM_001386200.1	NP_001373129.1	melanoma-associated antigen 4
NM_001386202.1	NP_001373131.1	melanoma-associated antigen 4
NM_001386203.1	NP_001373132.1	melanoma-associated antigen 4
NM_002362.4	NP_002353.3	melanoma-associated antigen 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12525503	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22842486	GOA
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	22842486	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGEA4 Protein Structure

MAGE_N

MAGE

0
100
200
300
317 a.a.

Protein Preferred Names	Protein Names
melanoma-associated antigen 4	MAGE-4 antigen

MAGEA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAGEA4	P43358	UVSSA	Homo sapiens	Q2YD98	Validated Y2H	32296183
Intra	MAGEA4	P43358	TRIM69	Homo sapiens	Q86WT6-2	Validated Y2H	32296183
Intra	MAGEA4	P43358	HDDC3	Homo sapiens	Q8N4P3-2	Validated Y2H	32296183
Intra	MAGEA4	P43358	PUDP	Homo sapiens	Q08623	Validated Y2H	32296183
Intra	MAGEA4	P43358	UBXN6	Homo sapiens	Q9BZV1	Validated Y2H	32296183
Intra	MAGEA4	P43358	RAD18	Homo sapiens	Q9NS91	Anti Tag CoIP	33961781
Intra	MAGEA4	P43358	RAD18	Homo sapiens	Q9NS91	Validated Y2H	32296183
Intra	MAGEA4	P43358	RAD18	Homo sapiens	Q9NS91	Anti Tag CoIP	28514442
Intra	MAGEA4	P43358	AMOT	Homo sapiens	Q4VCS5	Y2H Array	31515488
Intra	MAGEA4	P43358	AMOT	Homo sapiens	Q4VCS5	Anti Tag CoIP	33961781
Intra	MAGEA4	P43358	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	MAGEA4	P43358	TSPYL4	Homo sapiens	Q9UJ04	Anti Tag CoIP	33961781
Intra	MAGEA4	P43358	TSPYL4	Homo sapiens	Q9UJ04	Validated Y2H	32296183
Intra	MAGEA4	P43358	TSPYL4	Homo sapiens	Q9UJ04	Anti Tag CoIP	28514442
Intra	MAGEA4	P43358	ZBTB17	Homo sapiens	Q13105	Anti Tag CoIP	14739298
Intra	MAGEA4	P43358	ZNF576	Homo sapiens	Q9H609	Validated Y2H	32296183
Intra	MAGEA4	P43358	TSPYL	Homo sapiens	Q6FI91	Validated Y2H	32296183
Intra	MAGEA4	P43358	UQCRB	Homo sapiens	P14927	Anti Tag CoIP	33961781
Intra	MAGEA4	P43358	UQCRB	Homo sapiens	P14927	Y2H Pooling	16189514
Intra	MAGEA4	P43358	UQCRB	Homo sapiens	P14927	Anti Tag CoIP	28514442
Intra	MAGEA4	P43358	LDLRAP1	Homo sapiens	Q5SW96	Validated Y2H	32296183
Intra	MAGEA4	P43358	TRIM69	Homo sapiens	Q86WT6	Y2H Array	31515488
Intra	MAGEA4	P43358	TRIM69	Homo sapiens	Q86WT6	Y2H Pooling	16189514
Intra	MAGEA4	P43358	TEKT4	Homo sapiens	Q8WW24	Y2H Array	31515488
Intra	MAGEA4	P43358	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	32296183
Intra	MAGEA4	P43358	TEKT4	Homo sapiens	Q8WW24	Y2H Pooling	16189514
Intra	MAGEA4	P43358	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950
Intra	MAGEA4	P43358	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAGEA4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700420	MAGEA4 Protein, Human (HEK293, His)	P43358 (M1-V317)	≥ 90%, as determined by reducing SDS-PAGE.

MAGEA4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84325	MAGEA4 Antibody (YA4022)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P84325A	MAGEA4 Antibody (YA4022)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Seminoma	Seminoma, Pure
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Spermatocytoma	Spermatocytic Seminoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Testicular Spermatocytic Seminoma	Spermatocytic Seminoma
Testicular Leukemia
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Synovium Cancer	Malignant Tumor Of Synovium Synovial Neoplasm
Testicular Germ Cell Cancer	Germ Cell Tumor Of Testis Testicular Germ Cell Tumor Testicular Germ Cell Neoplasm Testicular Malignant Germ Cell Tumor
Testicular Disease	Testicular Dysfunction Testicular Diseases Disorder Of Testis Testis Disorder Testicular Disorders
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2269A	MAIT-203 acetate		99.12%	Unkown
HY-P11621	JWP24	Inhibitor	/	Unkown
HY-P11621A	JWP24 acetate	Inhibitor	/	Unkown
HY-P2269	MAIT-203		/	Unkown
HY-RS07969	MAGEA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21150	Magea4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27666	Magea4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Others	MAGEA4	NCBI