MAIT-203
MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.
For research use only. We do not sell to patients.
- Formula: C106H177N43O29
- Molecular Weight:2517.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MAIT-203 (10 μM and 25 μM; for 24 h) reduces Asef-APC interaction in a dose-dependent manner in HEK293T cells[1].
MAIT-203 (10 μM) significantly attenuates SW480 and HCT116 cell migration[1].
Incubation of SW480 cells with MAIT-203 (25, 50 μM;for 24 h) results in a dose-dependent decrease in the amount of the active form of CDC42, but not Rac1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 2517.85
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Formula C106H177N43O29
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Sequence
Cbz-Ala-Gly-Glu-Ala-{S-3cyclopentylalamine}-Tyr-Glu-Gly-Gly-Gly-Gly-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
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Sequence Shortening
Z-AGEA-{S-3cyclopentylalamine}-YEGGGGGRKKRRQRRR-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell migration
Cell migration is a method that plays an important role in wound healing, cell differentiation, embryonic development, etc.
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Cell invasion
Cell invasion is the ability of cells to migrate from one area to another via the extracellular matrix. Cell invasion is the response of normal and cancer cells to chemical and mechanical stimuli. Before migrating to a new region, the extracellular matrix is degraded by proteases within the cell. Cell invasion often occurs during wound repair, vascularization and inflammation, abnormal tissue invasion, and tumor cell metastasis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAIT-203 Related Classifications
HY-P2269 Related Classifications
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