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MAIT-203 

Cat. No.: HY-P2269
Handling Instructions

MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MAIT-203 Chemical Structure

MAIT-203 Chemical Structure

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Description

MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.

In Vitro

MAIT-203 (10 μM and 25 μM; for 24 h) reduces Asef-APC interaction in a dose-dependent manner in HEK293T cells[1].
MAIT-203 (10 μM) significantly attenuates SW480 and HCT116 cell migration[1].
Incubation of SW480 cells with MAIT-203 (25, 50 μM;for 24 h) results in a dose-dependent decrease in the amount of the active form of CDC42, but not Rac1[1].

Molecular Weight

2517.85

Formula

C₁₀₆H₁₇₇N₄₃O₂₉

Sequence

Z-Ala-Gly-Glu-Ala-{S-3cyclopentylalamine}-Tyr-Glu-Gly-Gly-Gly-Gly-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2

Sequence Shortening

Z-AGEA-{S-3cyclopentylalamine}-YEGGGGGRKKRRQRRR-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MAIT-203MAIT203MAIT 203Otherscyclopentyalanin-derivedpeptidomimeticadenomatouspolyposiscoliAPCAsefRhoGEF4APC-Sam68APC-striatinAPC-ARMmigrationinvasioncolorectalcancerInhibitorinhibitorinhibit

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MAIT-203
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HY-P2269
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