PPP3CB Antibody (YA6707)
(Synonyms: Calcineurin A beta antibody; Calcineurin A2 antibody; Calcineurin B, formerly antibody; Calmodulin dependent calcineurin A subunit beta isoform antibody; Calmodulin-dependent calcineurin A subunit beta isoform antibody; CALNA 2 antibody; CALNA2 antibody; CALNB antibody; CAM PRP catalytic subunit antibody; CAM-PRP catalytic subunit antibody; Calcineurin A beta antibody; Calcineurin A2 antibody; Calcineurin B, formerly antibody; Calmodulin dependent calcineurin A subunit beta isoform antibody; Calmodulin-dependent calcineurin A subunit beta isoform antibody; CALNA 2 antibody; CALNA2 antibody; CALNB antibody; CAM PRP catalytic subunit antibody; CAM-PRP catalytic subunit antibody; CNA2 antibody; CnAbeta antibody; PP2BB_HUMAN antibody; PP2Bbeta antibody; PPP3CB antibody; Protein phosphatase 2B, catalytic subunit, beta isoform, formerly antibody; Protein phosphatase 3 (formerly 2B) catalytic subunit beta isoform antibody; Protein phosphatase 3 catalytic subunit beta isoform antibody; Protein phosphatase 3 catalytic subunit beta isozyme antibody; Serine/threonine protein phosphatase 2B catalytic subunit beta isoform antibody; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform antibody; )PPP3CB Antibody (YA6707) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PPP3CB.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:200-1:1000 ICC 1:200 | 1:1000 |
Product Details
PPP3CB Antibody (YA6707) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PPP3CB.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 59 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 59 kDa
Synthetic peptide within Human Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform 265-318/524
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PPP3CB is a Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB. May play a role in skeletal muscle fiber type specification[1][2][3][4].
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Subcellular Localization
Cytoplasm
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Isoforms & Post-Translational Modification
P16298 has four isomers: P16298-1: 59024 Da (predicted); P16298-2: 58013 Da (predicted); P16298-3: 58081 Da (predicted); P16298-4: 59123 Da (predicted).
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Subunit
Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B) (PubMed:26794871)
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SwissProt ID
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Synonyms
Calcineurin A beta antibody; Calcineurin A2 antibody; Calcineurin B, formerly antibody; Calmodulin dependent calcineurin A subunit beta isoform antibody; Calmodulin-dependent calcineurin A subunit beta isoform antibody; CALNA 2 antibody; CALNA2 antibody; CALNB antibody; CAM PRP catalytic subunit antibody; CAM-PRP catalytic subunit antibody; Calcineurin A beta antibody; Calcineurin A2 antibody; Calcineurin B, formerly antibody; Calmodulin dependent calcineurin A subunit beta isoform antibody; Calmodulin-dependent calcineurin A subunit beta isoform antibody; CALNA 2 antibody; CALNA2 antibody; CALNB antibody; CAM PRP catalytic subunit antibody; CAM-PRP catalytic subunit antibody; CNA2 antibody; CnAbeta antibody; PP2BB_HUMAN antibody; PP2Bbeta antibody; PPP3CB antibody; Protein phosphatase 2B, catalytic subunit, beta isoform, formerly antibody; Protein phosphatase 3 (formerly 2B) catalytic subunit beta isoform antibody; Protein phosphatase 3 catalytic subunit beta isoform antibody; Protein phosphatase 3 catalytic subunit beta isozyme antibody; Serine/threonine protein phosphatase 2B catalytic subunit beta isoform antibody; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform antibody;
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