PPP3CB - protein phosphatase 3 catalytic subunit beta Gene

Homo sapiens

Also known as CNA2; CALNB; CALNA2; PP2Bbeta

Gene ID: 5532 | Gene type: protein coding

About PPP3CB

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,436,433-73,496,024 (from NCBI)

This gene has 6 transcripts (splice variants), 127 orthologues and 12 paralogues. Ubiquitous expression in brain (RPKM 40.2), fat (RPKM 17.4) and 24 other tissues.

Summary

Enables several functions, including Calmodulin binding activity; calmodulin-dependent protein Phosphatase activity; and protein Phosphatase 2B binding activity. Involved in calcineurin-NFAT signaling cascade; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in cytoplasm. Part of calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]

PPP3CB Products(5)

mRNA	Protein	Name
NM_001142353.3	NP_001135825.1	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform a
NM_001142354.3	NP_001135826.1	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform c
NM_001289968.2	NP_001276897.1	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform d
NM_001289969.2	NP_001276898.1	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform e
NM_021132.4	NP_066955.1	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform b

PPP3CB Protein Structure

Metallophos

0
100
200
300
400
524 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

CAM-PRP catalytic subunit

Related Diseases

Diseases

Alias

Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11024	PPP3CB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PPP3CB	VGNC	VGNC:82211
Mus musculus	PPP3CB	MGD	MGI:107163
Felis catus	PPP3CB	VGNC	VGNC:69020
Canis familiaris	PPP3CB	VGNC	VGNC:44919
Rattus norvegicus	PPP3CB	RGD	RGD:3383
Bos taurus	PPP3CB	VGNC	VGNC:33266

Name
Email *

	Sorry, but the email address you supplied was invalid.