Ephrin A1 Antibody (YA2657)
(Synonyms: B61; EFL1; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4)Ephrin A1 Antibody (YA2657) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ephrin A1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
Ephrin A1 Antibody (YA2657) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ephrin A1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 24 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 24 kDa
A synthesized peptide derived from human Ephrin A1 aa23-45.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Ephrin A1 cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis
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Subcellular Localization
Cell membrane; Lipid-anchor, GPI-anchor; Secreted
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Expression
Tissue_specificity:Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level)
Induction:By TNF and IL1B/interleukin-1 beta -
Isoforms & Post-Translational Modification
P20827 has 2 isomers: P20827-1: 23787 Da (predicted); P20827-2: 21246 Da (predicted).
Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form;N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization -
Subunit
Monomer. Homodimer. Forms heterodimers with EPHA2. Binds to the receptor tyrosine kinases EPHA2, EPHA3, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1
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SwissProt ID
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Synonyms
B61; EFL1; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4
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Research Field
Cardiovascular
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