EFNA1 - ephrin A1 Gene

Also Known as B61; EFL1; GMAN; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1942

About EFNA1

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,127,876-155,134,899 (from NCBI)

This gene has 5 transcripts (splice variants), 277 orthologues and 7 paralogues. Broad expression in placenta (RPKM 65.2), lung (RPKM 54.9) and 22 other tissues.

Summary

This gene encodes a member of the ephrin (EPH) family. The Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EphA2, EphA4, EphA5, EphA6, and EphA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

EFNA1 Products (2)

mRNA	Protein	Name
NM_004428.3	NP_004419.2	ephrin-A1 isoform a precursor
NM_182685.2	NP_872626.1	ephrin-A1 isoform b precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	11519828	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19525919	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IDA IDA: Inferred from direct assay	10655584	GOA
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	10655584	GOA
involved in ephrin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in negative regulation of proteolysis involved in protein catabolic process	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in positive regulation of amyloid-beta formation	IDA IDA: Inferred from direct assay	24217950	GOA
involved in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10655584	GOA
involved in positive regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in positive regulation of protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in protein stabilization	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	10655584	GOA
involved in substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	10655584	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EFNA1 Protein Structure

Ephrin

0
100
205 a.a.

Protein Preferred Names	Protein Names
ephrin-A1	TNF alpha-induced protein 4

EFNA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EFNA1	P20827	EPHA2	Homo sapiens	P29317	X-Ray Diffraction	19525919
Intra	EFNA1	P20827	EPHA2	Homo sapiens	P29317	Anti Tag CoIP	19573808
Intra	EFNA1	P20827	EPHA2	Homo sapiens	P29317	Anti Tag CoIP	22244754

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EFNA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70164	Ephrin-A1/EFNA1 Protein, Human (HEK293, His)	NP_004419.2 (D19-S182)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72662	Ephrin-A1/EFNA1 Protein, Human (HEK293, Fc)	P20827-1 (D19-S182)	≥ 90%, as determined by reducing SDS-PAGE.

EFNA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82912	Ephrin A1 Antibody (YA2657)	WB	Human

Related Diseases

Diseases	Alias
Cortical Senile Cataract
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04192	EFNA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17656	Efna1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24117	Efna1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EFNA1	VGNC	VGNC:72167
Canis familiaris	EFNA1	VGNC	VGNC:40226
Felis catus	EFNA1	VGNC	VGNC:61748
Bos taurus	EFNA1	VGNC	VGNC:28355
Rattus norvegicus	EFNA1	RGD	RGD:620388
Mus musculus	EFNA1	MGD	MGI:103236
Others	EFNA1	NCBI