CD11b Antibody (YA3751)(PBS only)
(Synonyms: CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6)CD11b Antibody (YA3751) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD11b.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CD11b Antibody (YA3751) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD11b.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 127 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 127 kDa
Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD11b is an Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development[1][2][3][4].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Membrane raft; Single-pass type I membrane protein
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Expression
Tissue_specificity:It is mainly expressed in monocytes and granulocytes (PubMed: 1346576) . It is also expressed in neutrophils (protein level) (PubMed: 21193407) . -
Isoforms & Post-Translational Modification
P11215 has 2 isomers: P11215-1: 127179 Da (predicted); P11215-2: 127307 Da (predicted).
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Subunit
Heterodimer of an alpha and a beta subunit. ITGAM associates with ITGB2. Found in a complex with CD177 and ITGB2/CD18 (PubMed:21193407). Interacts with JAM3 (PubMed:12208882, PubMed:15194813). Interacts with THBD (PubMed:27055590). Interacts with complement factor H/CFH; this interaction mediates adhesion of neutrophils to pathogens leading to pathogen clearance (PubMed:20008295, PubMed:9558116). Interacts with TMEM268; this interaction inhibits ITGAM degradation via the endosome-lysosome pathway (PubMed:38730209)
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SwissProt ID
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Synonyms
CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
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