RASSF5 (NORE1) Antibody (YA8358)
(Synonyms: Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3)RASSF5 (NORE1) Antibody (YA8358) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RASSF5 (NORE1).
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Host:
Mouse
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Isotype:
IgG
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Application:
FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 1:100 |
Product Details
RASSF5 (NORE1) Antibody (YA8358) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RASSF5 (NORE1).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 30.2 kDa
Full length human recombinant protein of human RASSF5 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RASSF5 is a Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis
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Subcellular Localization
Cytoplasm,Cytoplasm, cytoskeleton
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Expression
Tissue_Specificity: Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors -
Isoforms & Post-Translational Modification
Q8WWW0 has 3 isomers: Q8WWW0-1: 47090 Da (predicted); Q8WWW0-2: 30359 Da (predicted); Q8WWW0-3: 37433 Da (predicted).
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Subunit
Interacts directly with activated HRAS; a RASSF5-STK4/MST1 complex probably associates with activated HRAS (By similarity)
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SwissProt ID
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Synonyms
Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3
Documentation
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