JNK1 Antibody (YA5290)
(Synonyms: AI849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; MK08_HUMAN; p54 gamma; PRKM 8; PRKM8; Protein kinase JNK1; Protein kinase, mitogen-activated, 8; SAPK 1; SAPK gamma; SAPK1; Stress activated protein kinase JNK1; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1; Tyrosine protein kinase JAK1 .)JNK1 Antibody (YA5290) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to JNK1.
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Host:
Mouse
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:100 | 1:50-200 |
Product Details
JNK1 Antibody (YA5290) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to JNK1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 46,54 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Purified recombinant human JNK1 protein fragments expressed in E.coli.
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
c-Jun N-terminal kinase 1 (JNK1) is a mitogen-activated protein kinase (MAPK) that regulates autophagy, apoptosis, and cell proliferation across diverse tissues[1][2]. Mechanistically, JNK1 integrates stress signals from cytokines, reactive oxygen species, and metabolic cues to modulate downstream transcription factors and cytoplasmic substrates, influencing cell survival and differentiation[3][4]. In oligodendrocyte progenitor cells, JNK1 controls branching architecture, proliferation, and myelination, indicating a critical role in central nervous system development[5]. Compared with JNK2 and JNK3, JNK1 uniquely mediates inflammatory responses in arthritis and contributes to hepatic steatosis under high-fat diet conditions[6][7]. In disease models, JNK1 inhibition reduces hypoxia-induced autophagy and sensitizes cancer cells to chemotherapeutic agents, demonstrating isoform-specific therapeutic potential[8]. The development of JNK1-selective inhibitors remains challenging due to conserved ATP-binding sites among JNK isoforms; however, computational approaches using molecular descriptors have been applied to predict candidate inhibitors targeting autophagy regulation in cancer[1]. Collectively, JNK1 functions as a central regulator of stress signaling, with distinct contributions to metabolic, inflammatory, and neurological disease models, setting it apart from its isoform counterparts and informing experimental design for isoform-specific modulation[1][2][6][7][8].
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Subcellular Localization
Cytoplasm; Nucleus; Synapse
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Isoforms & Post-Translational Modification
P45983 has 5 isomers: P45983-1: 48296 Da (predicted); P45983-2: 44229 Da (predicted); P45983-3: 44022 Da (predicted); P45983-4: 48088 Da (predicted); P45983-5: 35333 Da (predicted).
Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme (PubMed:11062067). Phosphorylated by TAOK2 (PubMed:17158878). May be phosphorylated at Thr-183 and Tyr-185 by MAP3K1/MEKK1 (PubMed:17761173). Phosphorylated form is more concentrated at synapses than none-phosphorylated (By similarity) -
Subunit
Forms a complex with MAPK8IP1 and ARHGEF28 (By similarity). Found in a complex with SH3RF1, RAC1, MAP3K11/MLK3, MAP2K7/MKK7 and MAPK8IP1/JIP1.
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SwissProt ID
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Synonyms
AI849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; MK08_HUMAN; p54 gamma; PRKM 8; PRKM8; Protein kinase JNK1; Protein kinase, mitogen-activated, 8; SAPK 1; SAPK gamma; SAPK1; Stress activated protein kinase JNK1; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1; Tyrosine protein kinase JAK1 .
Documentation
References
[2]. Kumar A, et al. JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases. Future Med Chem. 2015;7(15):2065-86. [Content Brief]
[3]. Seki E, et al. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug;143(2):307-20. [Content Brief]
[4]. Shashikanth N, et al. Role of C-Jun N-Terminal Kinases on a Stressed Epithelium: Time for Testing Isoform Specificity. Biology (Basel). 2025 Jun 3;14(6):649. [Content Brief]
[5]. Lorenzati M, et al. c-Jun N-terminal kinase 1 (JNK1) modulates oligodendrocyte progenitor cell architecture, proliferation and myelination. Sci Rep. 2021 Mar 31;11(1):7264. [Content Brief]
[6]. Singh R, et al. Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology. 2009 Jan;49(1):87-96. [Content Brief]
[7]. Denninger K, et al. JNK1, but not JNK2, is required in two mechanistically distinct models of inflammatory arthritis. Am J Pathol. 2011 Oct;179(4):1884-93. [Content Brief]
[8]. Vasilevskaya IA, et al. JNK1 Inhibition Attenuates Hypoxia-Induced Autophagy and Sensitizes to Chemotherapy. Mol Cancer Res. 2016 Aug;14(8):753-63. [Content Brief]
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