MAPK8 - mitogen-activated protein kinase 8 Gene

Also Known as JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5599

About MAPK8

Cytogenetic location: 10q11.22 Genomic coordinates (GRCh38): 10:48,306,677-48,439,360 (from NCBI)

This gene has 16 transcripts (splice variants), 291 orthologues and 19 paralogues. Ubiquitous expression in brain (RPKM 9.4), thyroid (RPKM 7.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced Apoptosis. This kinase is also involved in UV radiation induced Apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, Apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

MAPK8 Products (27)

mRNA	Protein	Name
NM_001323329.2	NP_001310258.1	mitogen-activated protein kinase 8 isoform alpha2
XM_047425484.1	XP_047281440.1	mitogen-activated protein kinase 8 isoform X2
NM_001278548.2	NP_001265477.1	mitogen-activated protein kinase 8 isoform 5
XM_047425481.1	XP_047281437.1	mitogen-activated protein kinase 8 isoform X1
NM_001323302.2	NP_001310231.1	mitogen-activated protein kinase 8 isoform alpha1
NM_001323326.2	NP_001310255.1	mitogen-activated protein kinase 8 isoform alpha1
XM_024448080.2	XP_024303848.1	mitogen-activated protein kinase 8 isoform X2
NM_139046.4	NP_620634.1	mitogen-activated protein kinase 8 isoform beta1
NR_136584.2
NM_001323320.2	NP_001310249.1	mitogen-activated protein kinase 8 isoform 6
NM_001323321.2	NP_001310250.1	mitogen-activated protein kinase 8 isoform beta1
NM_001323327.2	NP_001310256.1	mitogen-activated protein kinase 8 isoform alpha1
NM_001278547.2	NP_001265476.1	mitogen-activated protein kinase 8 isoform beta2
XM_047425480.1	XP_047281436.1	mitogen-activated protein kinase 8 isoform X1
XM_024448079.2	XP_024303847.1	mitogen-activated protein kinase 8 isoform X1
NM_001323330.2	NP_001310259.1	mitogen-activated protein kinase 8 isoform beta2
NM_001323331.2	NP_001310260.1	mitogen-activated protein kinase 8 isoform alpha2
NR_136583.2
NM_001323328.2	NP_001310257.1	mitogen-activated protein kinase 8 isoform alpha2
NM_002750.3
NM_139049.4	NP_620637.1	mitogen-activated protein kinase 8 isoform alpha2
NM_001323324.2	NP_001310253.1	mitogen-activated protein kinase 8 isoform alpha1
NM_001323325.2	NP_001310254.1	mitogen-activated protein kinase 8 isoform beta1
XM_047425482.1	XP_047281438.1	mitogen-activated protein kinase 8 isoform X2
NR_136585.2
NM_001323322.2	NP_001310251.1	mitogen-activated protein kinase 8 isoform beta2
NM_001323323.2	NP_001310252.1	mitogen-activated protein kinase 8 isoform beta2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables JUN kinase activity	IDA IDA: Inferred from direct assay	8654373	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	14615289	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	20027304	GOA
enables histone deacetylase regulator activity	IMP IMP: Inferred from mutant phenotype	20027304	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10393177	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	11489891	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14967141	GOA
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	11865055	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	8654373	GOA
acts upstream of or within JUN phosphorylation	IDA IDA: Inferred from direct assay	14967141	GOA
involved in JUN phosphorylation	IDA IDA: Inferred from direct assay	21095239	GOA
involved in cellular response to amino acid starvation	IDA IDA: Inferred from direct assay	11096076	GOA
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	23776175	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	27568560	GOA
involved in cellular response to reactive oxygen species	IDA IDA: Inferred from direct assay	34048572	GOA
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	14967141	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	21095239	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	21095239	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15850461	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	21095239	GOA
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	28943315	GOA
involved in positive regulation of cyclase activity	IMP IMP: Inferred from mutant phenotype	22027397	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22065586	GOA
involved in positive regulation of protein metabolic process	IMP IMP: Inferred from mutant phenotype	22027397	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22441692	GOA
involved in regulation of protein localization	IDA IDA: Inferred from direct assay	20027304	GOA
acts upstream of or within response to UV	IDA IDA: Inferred from direct assay	14967141	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	22966201	GOA
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	11096076	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	20027304	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK8 Protein Structure

Pkinase

0
100
200
300
400
427 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase 8	JUN N-terminal kinase MAP kinase 8 c-Jun N-terminal kinase 1 stress-activated protein kinase 1 stress-activated protein kinase 1c

MAPK8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAPK8	P45983	CLDN6	Homo sapiens	P56747	IF	36935496
Intra	MAPK8	P45983	CLDN6	Homo sapiens	P56747	Anti Bait CoIP	36935496
Intra	MAPK8	P45983	RPTOR	Homo sapiens	Q8N122	Anti Bait CoIP	27043084
Cross	MAPK8	P45983	Mapk8ip1	Mus musculus	Q9WVI9-1	Anti Bait CoIP	11517249
Intra	MAPK8	P45983	MAP2K4	Homo sapiens	P45985	Pull Down	32707033
Intra	MAPK8	P45983	MAP2K4	Homo sapiens	P45985	Anti Tag CoIP	35271311
Intra	MAPK8	P45983	MAP2K7	Homo sapiens	O14733-2	Anti Tag CoIP	16533805
Intra	MAPK8	P45983	MAP2K7	Homo sapiens	O14733-2	Pull Down	16533805
Intra	MAPK8	P45983	H2AX	Homo sapiens	P16104	Anti Bait CoIP	19234442
Intra	MAPK8	P45983	CBL	Homo sapiens	P22681	Anti Bait CoIP	16982329
Intra	MAPK8	P45983	DUSP8	Homo sapiens	Q13202	Anti Tag CoIP	33961781
Intra	MAPK8	P45983	DUSP8	Homo sapiens	Q13202	Y2H	21900206
Intra	MAPK8	P45983	MAPK9	Homo sapiens	P45984	Anti Bait CoIP	25284480
Intra	MAPK8	P45983	MAPK9	Homo sapiens	P45984	Anti Tag CoIP	33961781
Intra	MAPK8	P45983	MAPK8IP1	Homo sapiens	Q9UQF2	Pull Down	16840345
Intra	MAPK8	P45983	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	25284480
Intra	MAPK8	P45983	JUN	Homo sapiens	P05412	Protein Kinase Assay	19527717
Intra	MAPK8	P45983	JUN	Homo sapiens	P05412	Protein Kinase Assay	16291755
Intra	MAPK8	P45983	JUN	Homo sapiens	P05412	In Gel Kinase Assay	15894542
Intra	MAPK8	P45983	JUN	Homo sapiens	P05412	Protein Kinase Assay	18003900

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPK8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73848	JNK1 Protein, Human (Inactive, sf9, GST)	P45983 (M1-R427)	≥ 90%, as determined by reducing SDS-PAGE.

MAPK8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80197	JNK1+JNK2+JNK3 Antibody (YA328)	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
HY-P80198	JNK1+JNK3 Antibody (YA327)	WB, IP	Mouse, Rat
HY-P80728	JNK1/2/3 Antibody (YA329)	WB, IP	Human, Mouse, Rat, Hamster
HY-P80728A	JNK1/2/3 Antibody (YA329)(PBS only)	WB, IP	Human, Mouse, Rat, Hamster
HY-P80729	JNK1 Antibody (YA720)	WB, ICC/IF	Human, Mouse, Rat
HY-P80729A	JNK1 Antibody (YA720)(PBS only)	WB, ICC/IF	Human, Mouse, Rat
HY-P80830	Phospho-JNK1/2/3 (Thr183) Antibody	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P80831	Phospho-JNK1 (Thr183/Tyr185) Antibody (YA180)	WB, IP	Human, Rat
HY-P80831A	Phospho-JNK1 (Thr183/Tyr185) Antibody (YA180)(PBS only)	WB, IP	Human, Rat
HY-P85598	JNK1 Antibody (YA5290)	WB, ICC/IF	Human, Mouse, Rat
HY-P86251	JNK1/2/3 Antibody (YA5943)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P88056	Phospho-JNK1 (Thr183/Tyr185) Antibody	WB, IHC-P, IHC-F, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Glioma
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Diabetes Mellitus	Diabetes
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Deafness, Autosomal Dominant 44	DFNA44 Autosomal Dominant Nonsyndromic Deafness 44 Autosomal Dominant Deafness 44 Deafness, Autosomal Dominant, 44 Deafness, Autosomal Dominant, Type 44
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Vagus Nerve Disease	Vagus Nerve Diseases Disorder Of Pneumogastric [10th] Nerve Disorder Of Vagal Nerve Disorder Of Vagus Nerve Vagus Nerve Disorder Disorders Of The Tenth Cranial Nerve Disorders Of 10th Cranial Nerve Disorder Of Pneumogastric Nerve
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Renal Fibrosis
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Monocytic Leukemia	Monocytic Leukaemia Schilling'S Leukaemia Schilling'S Leukemia M5b Acute Differentiated Monocytic Leukemia
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Cardiomyopathy, Familial Hypertrophic, 25	Hypertrophic Cardiomyopathy 25 CMH25 Cardiomyopathy, Hypertrophic, 25 Cardiomyopathy Familial Hypertrophic 25 Cardiomyopathy, Familial Hypertrophic 25 Cardiomyopathy, Hypertrophic, Type 25
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Cervical Non-Keratinizing Squamous Cell Carcinoma
Retinal Degeneration	Degeneration Of Retina
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2593	Isorhapontigenin		99.82%	Unkown
HY-128448	Carmoisine		98.66%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-RS08121	MAPK8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08123	Mapk8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183319	Anticancer agent 320		/	Unkown
HY-RS08122	Mapk8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08124	MAPK8IP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08125	MAPK8IP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08126	MAPK8IP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N20729	Eucommin A	Modulator	/	Unkown
HY-RS22065	Mapk8ip1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAPK8	VGNC	VGNC:68172
Macaca mulatta	MAPK8	VGNC	VGNC:74649
Mus musculus	MAPK8	MGD	MGI:1346861
Canis familiaris	MAPK8	VGNC	VGNC:43001
Rattus norvegicus	MAPK8	RGD	RGD:621506
Bos taurus	MAPK8	VGNC	VGNC:31223
Others	MAPK8	NCBI