2. Gene
  3. DUSP8 - dual specificity phosphatase 8 Gene

DUSP8 - dual specificity phosphatase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HB5; HVH8; HVH-5; C11orf81

Gene ID: 1850 | Gene type: protein coding

About DUSP8

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,554,051-1,572,848 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 208 orthologues and 30 paralogues. Broad expression in brain (RPKM 9.1), colon (RPKM 3.4) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and Insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]

DUSP8 Products(1)

mRNA Protein Name
NM_004420.3 NP_004411.2 dual specificity protein phosphatase 8

DUSP8 Protein Structure

Rhodanese

Rhodanese: Rhodanese-like domain (13 - 130)

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (168 - 298)

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  • 625 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 8

H1 phosphatase, vaccinia virus homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04069 DUSP8 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DUSP8 VGNC VGNC:102877
Canis familiaris DUSP8 VGNC VGNC:51865
Bos taurus DUSP8 VGNC VGNC:106719
Macaca mulatta DUSP8 VGNC VGNC:100918
Rattus norvegicus DUSP8 RGD RGD:1306425
Mus musculus DUSP8 MGD MGI:106626