Activin A Receptor Type IB Antibody (YA9722)
(Synonyms: Activin A receptor type 1B, Activin A receptor type II like kinase 4, Activin A type 1B receptor, Activin A type IB receptor, Activin receptor like kinase 4, Activin receptor type 1B, Activin receptor type IB, Activin receptor type-1B, Activin receptor-like kinase 4, ACTR IB)Activin A Receptor Type IB Antibody (YA9722) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Activin A Receptor Type IB.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:250 | 1:5000 | 1:500-1000 |
Product Details
Activin A Receptor Type IB Antibody (YA9722) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Activin A Receptor Type IB.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 57 kDa;
Recombinant protein of human Activin receptor type-1B (aa 24-126).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Activin A Receptor Type IB is a Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver -
Isoforms & Post-Translational Modification
P36896 has 5 isomers: P36896-1: 56807 Da (predicted); P36896-2: 53411 Da (predicted); P36896-3: 54270 Da (predicted); P36896-4: 61439 Da (predicted); P36896-5: 51725 Da (predicted).
Autophosphorylated. Phosphorylated by activin receptor type-2 (ACVR2A or ACVR2B) in response to activin-binding at serine and threonine residues in the GS domain. Phosphorylation of ACVR1B by activin receptor type-2 regulates association with SMAD7;Ubiquitinated. Level of ubiquitination is regulated by the SMAD7-SMURF1 complex;Ubiquitinated -
Subunit
Forms an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B) (PubMed:8196624, PubMed:8622651, PubMed:9032295). Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). Interacts with SMAD2 and SMAD3 (PubMed:9892009). Interacts with SMAD7 (PubMed:12023024, PubMed:16720724, PubMed:9892009). Interacts with FKBP1A (PubMed:16720724). Interacts with IGSF1 (PubMed:11266516). Interacts with CRIPTO (PubMed:11909953). Interacts with TDP2 (By similarity). Interacts with TSC22D1/TSC-22 (PubMed:21791611)
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SwissProt ID
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Synonyms
Activin A receptor type 1B, Activin A receptor type II like kinase 4, Activin A type 1B receptor, Activin A type IB receptor, Activin receptor like kinase 4, Activin receptor type 1B, Activin receptor type IB, Activin receptor type-1B, Activin receptor-like kinase 4, ACTR IB
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