CD86 Antibody (YA6374)(PBS only)

CD86 Antibody (YA6374) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD86.

Predicted band size: 37 kDa

P42081

942 [NCBI]

Shipping with blue ice.

Function：Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4 (PubMed:12196291). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity)|Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation|(Microbial infection) Acts as a receptor for adenovirus subgroup B

Subcellular Localization：Cell membrane

Expression：
Tissue_Specificity: Expressed by activated B-lymphocytes and monocytes

Isoforms & Post-Translational Modification：P42081 has 6 isomers: P42081-1: 37682 Da (predicted); P42081-3: 37007 Da (predicted); P42081-2: 12818 Da (predicted); P42081-4: 31293 Da (predicted); P42081-5: 24773 Da (predicted); P42081-6: 28420 Da (predicted).
Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation

Subunit：Homodimer

CD28LG2; FUN1; LAB72; Activation B7 2 antigen; Activation B7-2 antigen 3; CD86_HUMAN; Activation B7-2 antigen; Activation B72 antigen; B lymphocyte activation antigen B7 2; B lymphocyte activation antigen B72; B-lymphocyte activation antigen B7-2 2; B-lymphocyte activation antigen B7-2; B7 2; B7 2 antigen; B7; B7-2; B7.2; B70; B72 antigen; BU63; CD 86; CD28 antigen ligand 2 2; CD28 antigen ligand 2; Cd28l2; CD28LG2; CD86 antigen(CD28 antigen ligand 2, B7-2 antigen) 1, 2; CD86 antigen; CD86 molecule; CLS1; CTLA 4 counter receptor B7 2; CTLA 4 counter receptor B7.2; CTLA-4 counter-receptor B7.2 2, 3; CTLA4 counter receptor B72; Early T-cell costimulatory molecule 1; ETC-1; FUN 1; LAB72; Ly-58; Ly58; MB7; MB7-2; Membrane glycoprotein; MGC34413; T lymphocyte activation antigen CD86; T-lymphocyte activation antigen CD86; TS/A-2.