CD86 - CD86 molecule Gene

Also Known as B70; B7-2; B7.2; LAB72; CD28LG2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 942

About CD86

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:122,055,362-122,121,136 (from NCBI)

This gene has 9 transcripts (splice variants), 108 orthologues and 12 paralogues. Broad expression in appendix (RPKM 16.6), lymph node (RPKM 11.0) and 16 other tissues.

Summary

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

CD86 Products (5)

mRNA	Protein	Name
NM_001206924.2	NP_001193853.2	T-lymphocyte activation antigen CD86 isoform 4 precursor
NM_001206925.2	NP_001193854.2	T-lymphocyte activation antigen CD86 isoform 5
NM_006889.5	NP_008820.4	T-lymphocyte activation antigen CD86 isoform 2 precursor
NM_175862.5	NP_787058.5	T-lymphocyte activation antigen CD86 isoform 1 precursor
NM_176892.2	NP_795711.2	T-lymphocyte activation antigen CD86 isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9915850	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	24845157	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell activation	IDA IDA: Inferred from direct assay	7527824	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular exosome	IDA IDA: Inferred from direct assay	15908444	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD86 Protein Structure

V-set

Ig_2

0
100
200
300
329 a.a.

Protein Preferred Names	Protein Names
T-lymphocyte activation antigen CD86	B-lymphocyte activation antigen B7-2

CD86 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD86	P42081	CTLA4	Homo sapiens	P16410	X-Ray Diffraction	11279501
Intra	CD86	P42081	CTLA4	Homo sapiens	P16410	Protein Array	21982860
Intra	CD86	P42081	CTLA4	Homo sapiens	P16410	PLA	25241761

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD86 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7322	B7-2/CD86 Protein, Human (HEK293, Fc)	P42081-1 (L20-P247)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70795	B7-2/CD86 Protein, Human (HEK293, His)	AAH40261.1 (A24-P247)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75489	B7-2/CD86 Protein, Human (Biotinylated, HEK293, His)	P42081-1 (L26-H245)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78064	B7-2/CD86 Protein, Human (Biotinylated, HEK293, His-Avi)	P42081-1 (L26-P247)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78383	B7-2/CD86 Protein, Human (HEK293, His-Avi)	P42081-1 (L26-P247)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78899	B7-2/CD86 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P42081-1 (L26-P247)	≥ 95%, as determined by reducing SDS-PAGE.

CD86 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80609	CD86 Antibody	WB, IHC-P, ICC/IF, IP, FC	Human, Rat
HY-P84312	CD86 Antibody (YA4009)	WB, ELISA	Human
HY-P84312A	CD86 Antibody (YA4009)(PBS only)	WB, ELISA	Human
HY-P86649	CD86 Antibody (YA6341)	WB, IHC-P, ICC/IF, ELISA	Mouse
HY-P86682	CD86 Antibody (YA6374)	ICC/IF, FC	Human
HY-P86682A	CD86 Antibody (YA6374)(PBS only)	ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Plague	Yersiniosis Yersinia Infections Infection By Yersinia Pestis Pasteurella Pestis Infection Pestilential Fever Yersinia Pestis Infection
Cowpox	Yaba
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Paracoccidioidomycosis	Mucocutaneous-Lymphangitic Paracoccidioidomycosis Paracoccidioidal Mycosis Lobo Disease Lutz-Splendore-Almeida Disease Pcm Paracoccidioidal Granuloma South American Blastomycosis Lobomycosis Brazilian Blastomycosis Lutz Disease Brazilian Blastomycotic South American Blastomyces Infection Paracoccidioides Brasiliensis Infection Paracoccidioidomycosis Unspecified
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Myasthenia Gravis	MG Acquired Myasthenia Autoimmune Myasthenia Gravis Erb-Goldflam Disease Mg - [Myasthenia Gravis] Myasthenia Gravis Nos Myasthenia
Autoimmune Peripheral Neuropathy
Brucellosis	Mediterranean Fever Malta Fever Undulant Fever Gibraltar Fever Bang'S Disease Maltese Fever Cyprus Fever Rock Fever Brucellosis Infection Brucella Infection
Lymphohistiocytoid Mesothelioma
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Immunodeficiency With Hyper-Igm, Type 3	HIGM3 Immunodeficiency With Hyper Igm Type 3 Hyper-Igm Syndrome Type 3 Hyper-Igm Syndrome 3 Hyper-Igm Syndrome Due To Cd40 Deficiency Cd40 Deficiency Type 3 Hyper-Igm Immunodeficiency Hyper Igm Syndrome 3 Immunodeficiency With Hyper-Igm 3 Hyper-Igm Immunodeficiency Type 3 Immunodeficiency, With Hyper Igm, Type 3 Hyper-Igm Immunodeficiency Syndrome, Type 3
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Autoimmune Neuropathy
Myocarditis	Myocardial Inflammation Inflammatory Cardiomyopathy
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Parovarian Cyst	Cyst, Fimbrial Embryonic Fimbrial Cyst
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Temporal Arteritis	Polymyalgia Rheumatica Giant Cell Arteritis Cranial Arteritis Horton Disease Gca Horton'S Disease Rhizomelic Pseudopolyarthritis Arteritis Cranialis Arteritis Temporalis Horton'S Arteritis Horton'S Giant Cell Arteritis Horton'S Temporal Arteritis Horton'S Syndrome Gca - [Giant Cell Arteritis] Senile Arthritis Polymyalgia Arteritica Pmr - [Polymyalgia Rheumatica] Forestier-Certonciny Syndrome Rheumatic Polymyalgia Polymyalgia
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Autoimmune Myocarditis
Primary Bacterial Infectious Disease
Autoimmune Disease Of Central Nervous System
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Autoimmune Disease Of Musculoskeletal System
Goat Milk Allergy	Capra Hircus Milk Allergy
Autoimmune Disease Of Endocrine System
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Epididymis Adenocarcinoma	Adenocarcinoma Of The Epididymis
Epididymis Cancer	Malignant Tumor Of Epididymis Malignant Epididymal Tumor Malignant Neoplasm Of Epididymis Neoplasm Of Epididymis
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N6664	Gum arabic		/	Phase 3
HY-115870	AZD8154	Inhibitor	99.88%	Phase 2
HY-W016773	1,10-Decanediol		99.95%	Phase 1

Inhibitory Antibodies (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991424	GSK2618960	Inhibitor	95.66%	Phase 2
HY-P99821	Ravagalimab	Inhibitor	99.31%	Phase 2
HY-P99809	Quavonlimab	Inhibitor	≥99.0%	Phase 2
HY-P991566	KD6001	Inhibitor	/	Phase 2
HY-P991952	ADU-1604	Inhibitor	/	Phase 1
HY-P991961	REGN4659	Inhibitor	/	Phase 1
HY-P991366	IBI-397	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148980A	Polyinosinic acid sodium		91.5%	Unkown
HY-150749A	ODN D-SL03 sodium		98.57%	Unkown
HY-W722277A	LCC-12 formate	Inhibitor	99.90%	Unkown
HY-141677	INCB059872	Inhibitor	99.60%	Unkown
HY-141677A	INCB059872 dihydrochloride	Inhibitor	99.64%	Unkown
HY-138794B	XL177B		99.36%	Unkown
HY-150749	ODN D-SL03	Inducer	99.82%	Unkown
HY-N10116A	Calamenene		/	Unkown
HY-148980	Polyinosinic acid		/	Unkown
HY-141677B	INCB059872 tosylate	Inhibitor	/	Unkown
HY-141677C	INCB059872 TFA	Inhibitor	/	Unkown
HY-143410	Anti-inflammatory agent 16	Inhibitor	/	Unkown
HY-144675	LSD1-IN-13	Inhibitor	/	Unkown
HY-144675A	LSD1-IN-13 hydrochloride	Inhibitor	/	Unkown
HY-150740	ODN 21595	Inhibitor	/	Unkown
HY-152201	BTK-IN-18	Inhibitor	/	Unkown
HY-160227	ORN 06	Activator	/	Unkown
HY-161833	HSP90-IN-31	Inhibitor	/	Unkown
HY-169819	Calcium influx inducer compound 634		/	Unkown
HY-170403	LSD1-IN-38	Inhibitor	/	Unkown
HY-173070	TLR7 agonist 29		/	Unkown
HY-179336	TLR7/8 agonist 14		/	Unkown
HY-181781	LSD1-IN-48		/	Unkown
HY-RS02274	CD86 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W016773S	1,10-Decanediol-d20		/	Unkown
HY-150740A	ODN 21595 sodium	Inhibitor	/	Unkown
HY-168384	M04		/	Unkown
HY-184441	CD28-IN-4	Inhibitor	/	Unkown
HY-RS16645	Cd86 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23079	Cd86 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990260	Anti-Mouse CD86/B7-2 Antibody (GL-1)	Inhibitor	99.17%	Unkown
HY-P990127	Anti-Mouse CD80/B7-1 Antibody (RM80)	Inhibitor	95%	Unkown
HY-P990261	Anti-Mouse CD83 Antibody (Michel-17)	Inhibitor	98.722%	Unkown
HY-P991759	Anti-Rat CD86 Antibody (OX-48)	Inhibitor	/	Unkown
HY-P991777	Anti-Mouse CD86/B7-2 Antibody (2D10)	Inhibitor	/	Unkown
HY-P991908	Anti-CD86 Antibody (3D1)		/	Unkown
HY-P991918	KHK2840	Agonist	/	Unkown
HY-P992408	MEDI-5083		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CD86	VGNC	VGNC:60643
Rattus norvegicus	CD86	RGD	RGD:628714
Bos taurus	CD86	VGNC	VGNC:27051
Canis familiaris	CD86	VGNC	VGNC:38979
Macaca mulatta	CD86	VGNC	VGNC:70785
Mus musculus	CD86	MGD	MGI:101773
Others	CD86	NCBI