2. Epigenetics
  3. Histone Demethylase
  4. INCB059872 dihydrochloride

INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia.

For research use only. We do not sell to patients.

INCB059872 dihydrochloride Chemical Structure

INCB059872 dihydrochloride Chemical Structure

Size Price Stock Quantity
1 mg USD 350 In-stock
5 mg USD 950 In-stock
10 mg USD 1500 In-stock
25 mg USD 3000 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of INCB059872 dihydrochloride:

INCB059872 dihydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Histone Demethylase Isoform Specific Products:

View All Isoforms
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia[1].

IC50 & Target[1]

KDM1/LSD1

 

In Vitro

INCB059872 (25 nM; 48 hours; 293T cells) dihydrochloride increases enhancer activity and gene expression[1].
INCB059872 (25 nM; 24 hours; THP-1 cells) dihydrochloride makes THP-1 show a growth defect within one cell doubling time or approximately 3 days[1].
INCB059872 (THP-1 cells) dihydrochloride regulates PRO-seq analysis identifies genes and enhancers[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

INCB059872 dihydrochloride Related Antibodies

Western Blot Analysis[1]

Cell Line: 293T cells
Concentration: 250 nM
Incubation Time: 48 hours
Result: Increased enhancer activity and gene expression.
In Vivo

INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 days; C57BL/6J mice) dihydrochloride makes single-cell RNA-seq revealing changes in bone marrow progenitor populations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice[1]
Dosage: 10 mg/kg
Administration: p.o.; 0, 4, or 6 days
Result: Single-cell RNA-seq revealed changes in bone marrow progenitor populations.
Clinical Trial
Molecular Weight

459.45

Formula

C23H36Cl2N2O3
Appearance

Solid

Color

White to light yellow

SMILES

OC(C1(CCC1)CN2CCC(COC)(CC2)CN[C@H]3[C@@](C4=CC=CC=C4)([H])C3)=O.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 3.57 mg/mL (7.77 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1765 mL 10.8826 mL 21.7652 mL
5 mM 0.4353 mL 2.1765 mL 4.3530 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1765 mL 10.8826 mL 21.7652 mL 54.4129 mL
5 mM 0.4353 mL 2.1765 mL 4.3530 mL 10.8826 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

INCB059872 dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

INCB059872INCB 059872INCB-059872Histone DemethylasepotentselectiveirreversibleLysine-SpecificDemethylasemyeloidleukemiaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
INCB059872 dihydrochloride
Cat. No.:
HY-141677A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.