TLR7 agonist 29
TLR7 agonist 29 (Compound 1) is the agonist for TLR7 with an EC50 of 5.2 nM for human TLR7 (EC50 for mouse TLR7 is 48.2 nM). TLR7 agonist 29 activates bone marrow-derived macrophages (BMDMs), stimulates myeloid cells in the tumor microenvironment, promotes the expression of PD-L1, CD86 and IFN-α. TLR7 agonist 29 can be used as payload for synthesis of ADC.
For research use only. We do not sell to patients.
- CAS No.: 2275612-76-3
- Formula: C20H27N7O2
- Molecular Weight:397.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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human TLR7 5.2 nM (EC50) |
mTLR7 48.2 nM (EC50) |
Chemical Information
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CAS No. 2275612-76-3
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Molecular Weight 397.47
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Formula C20H27N7O2
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SMILES
NC1=C2C(N(CC3=CN=C(CNC4CCC4)C=C3)C(O)=N2)=NC(OCCCC)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TLR7 agonist 29 Related Classifications
HY-173070 Related Classifications
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