LSD1-IN-38
LSD1-IN-38 (Compound 23e) is a reversible, orally active inhibitor for lysine specific demethylase 1 (LSD1) with an IC50 of 1.2 nM. LSD1-IN-38 inhibits the proliferation of cancer cells MV4-11, Kasumi-1 and NCI-H526, with IC50 of 5, 4 and 11 nM, respectively. LSD1-IN-38 activates CD86 expression with an EC50 of 0.034 μM, and induces differentiation in MV4−11 cell. LSD1-IN-38 exhibits antitumor efficacy in mouse models.
For research use only. We do not sell to patients.
- Formula: C30H29F4N5
- Molecular Weight:535.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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LSD1 1.2 nM (IC50) |
Chemical Information
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Molecular Weight 535.58
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Formula C30H29F4N5
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SMILES
FC1=C(C#N)C=CC(C2=C(N=CC3=C2C=C(CN4C[C@@H](N)CC4)N3CC(F)(F)F)C5=CC(C)=C(C)C=C5C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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