CD86 Antibody (YA4009)
(Synonyms: B70; B7-2; LAB72; CD28LG2; MGC34413; CD86)Based on 1 Customer Validation
CD86 Antibody (YA4009) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD86.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ELISA
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Reactivity :
Human
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Formulation:
Supplied in ascitic fluid containing 0.03% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
CD86 Antibody (YA4009) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD86.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 52 kDa
Purified recombinant fragment (Aa269-329) of human CD86 expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in ascitic fluid containing 0.03% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD86 (B7-2) is an immune co-stimulatory molecule expressed on the surface of antigen-presenting cells that regulates T-cell activation through binding to CD28 or CTLA-4 on T cells; it serves as a classic marker in research concerning dendritic cell maturation, macrophage polarization, tumor immunity, autoimmunity, infection, and transplant immunology.
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Expressed on activated B-cells -
Isoforms & Post-Translational Modification
CD86 has 2 isomers: P42082-1: 34666 Da (predicted); P42082-2: 33962 Da (predicted).
Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation -
Subunit
Homodimer. Interacts (via cytoplasmic domain) with PHB1 and PHB2; the interactions increases after priming with CD40.
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SwissProt ID
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Synonyms
B70; B7-2; LAB72; CD28LG2; MGC34413; CD86
Documentation
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