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CD86 Antibody (YA6341)

(Synonyms: T-lymphocyte activation antigen CD86; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD antigen CD86; )
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CD86 Antibody (YA6341) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD86.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG/Kappa

  • Application:

    WB, IHC-P, ICC/IF, ELISA

  • Reactivity :

    Mouse

  • Formulation:

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Conjugation:
    Non-conjugated
  • CD86 Antibody (YA6341) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Related Products:
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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1000 1:500-5000 1:200-1000 1:5000-20000

Product Details

Description

CD86 Antibody (YA6341) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD86.

  • Host Rabbit
  • Clonality Monoclonal
  • Species Reactivity
    Mouse
  • Calculated Molecular Weight Predicted band size: 60-80 kDa
Purification

Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG/Kappa

RRID

AB_3719196

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CD86 (B7-2) is an immune co-stimulatory molecule expressed on the surface of antigen-presenting cells that regulates T-cell activation through binding to CD28 or CTLA-4 on T cells; it serves as a classic marker in research concerning dendritic cell maturation, macrophage polarization, tumor immunity, autoimmunity, infection, and transplant immunology.

  • Subcellular Localization

    Cell membrane; Single-pass type I membrane protein

  • Expression


    Tissue_specificity:Expressed on activated B-cells

  • Isoforms & Post-Translational Modification

    CD86 has 2 isomers: P42082-1: 34666 Da (predicted); P42082-2: 33962 Da (predicted).
    Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation

  • Subunit

    Homodimer. Interacts (via cytoplasmic domain) with PHB1 and PHB2; the interactions increases after priming with CD40.

  • SwissProt ID

    P42081

  • Gene ID
    942 [NCBI]
  • Synonyms

    T-lymphocyte activation antigen CD86; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD antigen CD86;

CD86 Antibody (YA6341) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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