BTK-IN-18
BTK-IN-18 is a potent, reversible BTK inhibitor with an IC50 of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo.
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- No. CAS: 1374239-71-0
- Fòrmula: C20H22Cl2N6O
- Peso molecular:433.33
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B-cell | IC50 |
0.025 μM
Compound: 41
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Inhibition of B cell proliferation in PBMC (unknown origin) in the presence of anti-IgM and IL-4
Inhibition of B cell proliferation in PBMC (unknown origin) in the presence of anti-IgM and IL-4
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[PMID: 36538993] |
| B-cell | IC50 |
0.05 μM
Compound: 41
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Inhibition of B cell proliferation in PBMC (unknown origin)
Inhibition of B cell proliferation in PBMC (unknown origin)
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[PMID: 36538993] |
In Vivo
BTK-IN-18 (iv; 1 mg/kg) has a T1/2 of 5.3 hours, a CL of 19 mL/min/kg, and a Vss of 1.3 L/kg for rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[1]
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Dosage:10, 25, 45 mg/kg
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Administration:IP; single dose
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Result:Caused robust dose-dependent inhibition of both CD69 and CD86 (74.8 %, 50.3 %, and 21.5 % respectively).
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Animal Model:
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Dosage:
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Administration:
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Result:Pharmacokinetic Parameters of BTK-IN-18 in rats[1].
IV (1 mg/kg) PO (5 mg/kg) Tmax (h) 1.6 Cmax (h∗mg/mL) 321 AUCinfi (h∗mg/mL) 1013 1421 t1/2 (ng/mL) 5.3 CL (mL/min/kg) 19 Vss (L/kg) 1.3 F (%) 23%
Chemical Information
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No. CAS 1374239-71-0
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Peso molecular 433.33
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Fòrmula C20H22Cl2N6O
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SMILES
C[C@@H]1[C@@H](CCCN1C(CNC2=CC(Cl)=CC(Cl)=C2)=O)NC3=C4C=CNC4=NC=N3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTK-IN-18 Related Classifications
HY-152201 Related Classifications
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