BTK-IN-18
BTK-IN-18 is a potent, reversible BTK inhibitor with an IC50 of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo.
For research use only. We do not sell to patients.
- CAS No.: 1374239-71-0
- Formula: C20H22Cl2N6O
- Molecular Weight:433.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B-cell | IC50 |
0.025 μM
Compound: 41
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Inhibition of B cell proliferation in PBMC (unknown origin) in the presence of anti-IgM and IL-4
Inhibition of B cell proliferation in PBMC (unknown origin) in the presence of anti-IgM and IL-4
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[PMID: 36538993] |
| B-cell | IC50 |
0.05 μM
Compound: 41
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Inhibition of B cell proliferation in PBMC (unknown origin)
Inhibition of B cell proliferation in PBMC (unknown origin)
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[PMID: 36538993] |
In Vivo
BTK-IN-18 (iv; 1 mg/kg) has a T1/2 of 5.3 hours, a CL of 19 mL/min/kg, and a Vss of 1.3 L/kg for rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[1]
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Dosage:10, 25, 45 mg/kg
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Administration:IP; single dose
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Result:Caused robust dose-dependent inhibition of both CD69 and CD86 (74.8 %, 50.3 %, and 21.5 % respectively).
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Animal Model:
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Dosage:
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Administration:
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Result:Pharmacokinetic Parameters of BTK-IN-18 in rats[1].
IV (1 mg/kg) PO (5 mg/kg) Tmax (h) 1.6 Cmax (h∗mg/mL) 321 AUCinfi (h∗mg/mL) 1013 1421 t1/2 (ng/mL) 5.3 CL (mL/min/kg) 19 Vss (L/kg) 1.3 F (%) 23%
Chemical Information
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CAS No. 1374239-71-0
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Molecular Weight 433.33
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Formula C20H22Cl2N6O
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SMILES
C[C@@H]1[C@@H](CCCN1C(CNC2=CC(Cl)=CC(Cl)=C2)=O)NC3=C4C=CNC4=NC=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTK-IN-18 Related Classifications
HY-152201 Related Classifications
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