Anti-Mouse CD86/B7-2 Antibody (GL-1)
Based on 1 Customer Validation
Anti-Mouse CD86/B7-2 Antibody (GL-1) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD86/B7-2. Anti-Mouse CD86/B7-2 Antibody (GL-1) can be used for the researches of inflammation and immunology, such as allergic pulmonary inflammation.
For research use only. We do not sell to patients.
- Purity: 99.17%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG2a kappa
Mouse
CD86/B7-2
Anti-Mouse CD86/B7-2 Antibody (GL-1) (7 days) induces immunomodulatory cells production in splenocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anti-Mouse CD86/B7-2 Antibody (GL-1) (400 μg, i.p., every other day for 4 times) alleviates inflammation in ovalbumin-induced allergic pulmonary inflammation mice models[3].
Anti-Mouse CD86/B7-2 Antibody (GL-1) (200 μg, i.p., a single dose) prolongs survival in cardiac allografts mice models[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ovalbumin-induced allergic pulmonary inflammation mice models[3]
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Dosage:400 μg
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Administration:Intraperitoneally injection (the first doses via tail vein), every other day for 4 times
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Result:Decreased expression of CD25 on CD4+ T cells.
Decreased allergen-induced AHR and the expansion of eosinophil subset in the BAL.
Showed slightly attenuated inflammation.
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Animal Model:Cardiac allografts mice models[4]
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Dosage:200 μg
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Administration:Intraperitoneally injection
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Result:Led to more than 2 months allograft survival in all mice.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo CD86 blockade; Flow cytometry
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD86/B7-2 Antibody (GL-1)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Forgioni A, et al. Anti-Inflammatory Effects of Ex Vivo-Generated Donor Antigen-Specific Immunomodulatory Cells on Pancreatic Islet Transplantation. Cell Transplant. 2025 Jan-Dec;34:9636897251317887. [Content Brief]
[2]. Perrin PJ, et al. Opposing effects of CTLA4-Ig and anti-CD80 (B7-1) plus anti-CD86 (B7-2) on experimental allergic encephalomyelitis. J Neuroimmunol. 1996 Mar;65(1):31-9. [Content Brief]
[3]. Mark DA, et al. Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation. Int Immunol. 1998 Nov;10(11):1647-55. [Content Brief]
[4]. Judge TA, et al. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival. J Immunol. 1999 Feb 15;162(4):1947-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD86/B7-2 Antibody (GL-1) Related Classifications
HY-P990260 Related Classifications
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